Patched genes and uses related thereto

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S325000

Reexamination Certificate

active

06946257

ABSTRACT:
Methods are provided for identifying agents that decrease hedgehog signal transduction for ameliorating an effect of loss of function of a patched gene in a mammalian cell.

REFERENCES:
patent: 5935810 (1999-08-01), Friedman et al.
Kato(Nippon Yakurigaku Zasshi. Folia Pharmacoligica Japonica(102(3): AN 94010590, 1993.
Gailani et al (J. Nat. Canc. Inst. 89(15): 1103-1109, Aug. 1997).
Pennisi, Science 272: 1583-1584,Jun. 1996.
Fan et al (Cell 81(3): 457-465, May 5, 1995).
Altaba et al (Cell 90:193-196, 1997).
Muller et al (Development 127: 2999-3007, 2000).
Krishnan et al (Science 278: 1947-1950, (Dec. 12, 1997).
Alexander Noveen et al., cAMP, an Activator of Protein Kinase A, Suppresses the Expression of Sonic Hedgehog, Biochemical and Biophysical Research Communications, 219, pp. 180-185 (1996) Article No. 0202.
Willis Li et al., Function of Protein Kinase A in Hedgehog Signal Transduction and Drosophila Imaginal Disc Development, Cell, vol. 80, pp. 553-562, Feb. 24, 1995.
Matthias Hammerschmidt et al., Protein kinase A is a common negative regulator of Hedgehog signaling in the vertebrate embryo, Genes & Development, 10: pp. 647-658.
Alberts, eds., Molecular Biology of the Cell, G-10 (1994).
Chavrier et al., “The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach”, Gene 112: 261-264 (1992).
Ma et al., “Molecular Cloning and Characterization of rKlk10, cDNA Encoding T-Kininogenase from Rat Submandibular Gland and Kindney”, Biochemistry 31: 10922-10928.
Thummel et al., “Vectors forDrosophilaP-elment-mediated transformation and tissue culture transfection”, Gene 74: 445-446 (1988).
Bowie et al.; Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions; Science 247:1306-1310 (Mar. 16, 1990).
Forbes et al.; “Genetic Analysis of Hedgehod signalling in the Drosophilia Embryo”, Development(Supplement), pp 115-124 (1993).
Nakano et al.; “A Protein With Several Possible Membrane-Spanning Domains Encoded by the Drosophila Segment Polarity Gene Patched”, Nature, 341: 508-513 (Oct. 12, 1989).
Ngo et al.; “ Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox ”, Birkhauser, Boston 1994, pp. 491-495.
Wells A. James; “ Additivity of Mutational Effects in Proteins ”; Biochemistry, 39(37): 8509-8517 (Sep. 18, 1990).
Burke, R., and Besler K., “Hedgehog signaling in Drosophila eye and limb development-conserved machinery, divergent roles?”, Curr. Opin. Neurobiol., 7(1): 55-61 (1997).
Buscher, D. et al., “Evidence for Genetic Control of Sonic Hedgehog by Gli3 in Mouse Limb Development”, Mech. Dev., 62 (2):175-182 (1997).
Forbes et al., “Genetic analysis of hedgehog signalling in the Drosophila embryo”, Development 1993 Supplement pp. 115-124 (1993).
Hidalgo Alicia, “Interaction between segment polarity genes and the generation of the segmental pattern inDrosophila”, Mechanisms of Development 35 :77-87(1991).
Hidalgo Alicia, “Three distinct roles for the engrailed gene in Drosophila wing development”, Current Biology (4)12 : 1087-1098 (1994).
Platt A. K. et al., “Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between files and mice”, Mechanisms of Development 62:121-135 (1997).
Sampedro J. and Guerrero I., “Unrestricted expression of the Drosophila gene patched allows a normal segment polarity”, Nature 353 : 187-190 (Sep. 12, 1991).
Sánchez-Herrero et al., “The fu gene discriminaes between pathways to control dpp expression in Drosophila imaginal discs”, Mechanisms of Development 55: 159-170 (1996).
Scott P. Matthew, “Hox genes Arms and the Man”, Nature Genetics 15: 117-118 (Feb. 1997).
Strutt I. David and Miodzik Merek, “The regulation of hedgehog and decapentaplegic during Drosophila eye imaginal disc development”, Mechanisms of Development 58: 39-50 (1996).
Taylor et al., “Contrasting distributions of patched and hedgehog proteins in theDrosophilaembryo”, Mechanisms of Development 42:89-96 (1993).
Weed et al., “The Role of Sonic Hedgehog in Vertebrate Development”, Matrix Biology 16 : 53-58 (1997).
Gailani, M. and Bale, A., “Developmental genes and cancer: role of patched in basal cell carcinoma of the skin”,J. Natl. Cancer Inst., 89(15): 1103-1109 (1997).
Sisson, J. et al., “Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway”,Cell, 90(2): 235-245 (1997).
Vorechovsky, I. et al, “Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumors”,Oncogene, 15(3): 361-366 (1997).
Loftus, S., et al., “Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostatis gene”,Science, 277(5323): 232-235 (1997).
Struhl, G. et al., “Hedgehog acts by distinct gradient and signal relay mechanisms to organize cell type and cell polarity in the Drosophila abdomen”,Development, 124(11): 2155-2165 (1997).
Bale, A., “Variable expressivity of patched mutations in flies and humans”,Am. J. Human Genet., 60(1): 10-12 (1997).
Chen, E. and Baker, B., “Compartmental organization of the Drosophila genital imaginal disks”,Development, 124(1): 205-218 (1997).
Jensen, A. and Wallace, V., “Expression of Sonic hedgehog and its putative role as a precursor cell mitogen in the developing mouse retina”,Development, 124(2): 363-371 (1997).
Hepker, J. et al., “Drosophila cubitusinterruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes”,Development, 124(2): 549-558 (1997).
Nakamura, T. et al., “Induction of osteogenic differentiation by hedgehog proteins”,Biochem. Biophys. Res. Comm., 237(2): 465-469 (1997).
Grindley, J. et al., “Evidence for the involvement of the Gli gene family in embryonic mouse lung development”,Dev. Biol., 188(2): 337-348 (1997).
Alcedo, J. And Noli, M., “Hedgehog and its patched-smoothened receptor complex: a novel signalling mechanism at the cell surface”,Biol. Chem., 378(7): 583-590 (1997).
Hynes, M. et al., “Control of cell pattern in the neural tube by zinc finger transcription factor and oncogene Gli-1”,Neuron, 19(1): 15-26 (1997).
Takabatae, T. et al., “Hedgehog and patched gene expression in adult ocular tissues”,FEBS Letters, 410(2-3): 485-489 (1997).
Akiyama, H. et al., “Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signaling molecules during chondrogenesis and cartilege differentiation in conal mouse EC cells, ATDC5”,Biophys. Res. Comm., 235(1):142-147 (1997).
Oro, A. et al., “Basal cell carcinomas in mice overexressing sonic hedgehog”,Science, 276(5313): 817-821 (1997).
Bhat, K. and Schedl, P., “Requirement for engrailed and invected genes reveals novel regulatory interactions between engrailed/invected, patched, gooseberry and wingless during Drosophila neurogenesis”,Development, 124(9): 1675-1688 (1997).
Akimaru, H. et al., “Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling”,Nature, 386(6626): 735-738 (1997).
Epps, J. et al., “Oroshigane, a new segment polarity gene ofDrosophila melanogaster, functions in hedgehog signal transduction”,Genetics, 145(4): 1041-1052 (1997).
Von Ohlen, T. et al., “Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein”,Proc. Natl. Acad. Sci. USA, 94(6): 2404-2409 (1997).
Rogers, G. et al., “Patched gene mutation screening in patientts with basal cell nevus syndrome using bi-directional dideoxy fingerprinting”,J. Invest. Dermatol. Abstracts, 108(4):598, # 364, (1997).
Bellusci, S. et al., “In

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Patched genes and uses related thereto does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Patched genes and uses related thereto, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Patched genes and uses related thereto will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3425853

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.