Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-05-31
2000-02-22
Campell, Bruce R.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 435325, 536 235, 536 2431, C12P 1934, C12Q 168, C07H 2102, C07H 2104
Patent
active
06027882&
ABSTRACT:
Methods for isolating patched genes, particularly mammalian patched genes, including mouse and human patched genes, as well as invertebrate patched genes and sequences, are provided. Loss-of function of the patched is associated with the occurrence of human cancers, particularly basal cell carcinomas of the skin. The cancers may be familial, having as a component of risk an inherited genetic predisposition, or may be sporadic. Therefore, methods for using the patched gene as a diagnostic for assessing a genetic predisposition to cancer, and to identify specific cancers having mutations in this gene, are disclosed.
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Epstein Ervin
Goodrich Lisa V.
Johnson Ronald L.
Oro Tony
Scott Matthew P.
Arnold Beth
Campell Bruce R.
Martin Jill D.
The Regents of the University of California
Vincent Matthew P.
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