Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1998-05-20
2000-04-18
Brusca, John S.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 911, 435325, 4353201, 536 235, C12P 2100, C12P 1934, C12N 1563, C12N 500, C07H 2104
Patent
active
060514000
ABSTRACT:
Patched-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Patched-2 polypeptides and polynucleotides in therapy, and diagnostic assays for such.
REFERENCES:
Concordet et al., "Spatial regulation of a zebrafish patched homologue refects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning", Development vol. 122, pp. 2835-2845 (1996).
Takabatake et al., "Hedgehog and patched gene expression in adult ocular tissues", FEBS Letters 410, pp. 485-489 (1997).
GenBank Accession Nos. AB010833 and AB000847.
Motoyama et al., "Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog", Nature Genetics, vol. 18, pp. 104-106, Feb. 1998.
Barnes Michael R
Kelsell David P
Testa Tania Tamson
Brusca John S.
Hecht Elizabeth J.
King William T.
Sandals William
SmithKline Beecham Plc
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