Patched-2 polypeptides and polynucleotides

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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435 911, 435325, 4353201, 536 235, C12P 2100, C12P 1934, C12N 1563, C12N 500, C07H 2104

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060514000

ABSTRACT:
Patched-2 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing Patched-2 polypeptides and polynucleotides in therapy, and diagnostic assays for such.

REFERENCES:
Concordet et al., "Spatial regulation of a zebrafish patched homologue refects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning", Development vol. 122, pp. 2835-2845 (1996).
Takabatake et al., "Hedgehog and patched gene expression in adult ocular tissues", FEBS Letters 410, pp. 485-489 (1997).
GenBank Accession Nos. AB010833 and AB000847.
Motoyama et al., "Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog", Nature Genetics, vol. 18, pp. 104-106, Feb. 1998.

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