Patch for transdermal administration of volatile pharmaceuticall

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...

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Details

424448, 514946, A61L 1500

Patent

active

054627460

ABSTRACT:
The invention relates to a patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature which comprises a multi-element system comprising
(a) a matrix having distributed therein as the drug said volatile active ingredient or a physiologically acceptable salt thereof, the matrix comprising a pressure-sensitive adhesive,
(b) an element of a pressure-sensitive adhesive composition which--where (a) contains a salt--contains basic groups to liberate the free base from its salt,
(c) a backing layer impermeable to the diffusable ingredients of (a) and (b), and
(d) a release liner impermeable to the diffusable ingredients of (a) and (b),
matrix (a) or at least a part of (b), whichever is in contact with release liner (d), having a tack sufficient for affixing the patch to the skin, any part of (b) positioned between matrix (a) and release liner (d) being permeable for the deprenyl or the salt thereof or both. The invention also relates to a process for preparing such patch and to a process for treating a patient suffering from Parkinson's or Alzheimer's disease with such patch.

REFERENCES:
patent: 4666441 (1987-05-01), Andriola et al.
patent: 4861800 (1989-08-01), Buyske
patent: 4911707 (1990-03-01), Heiber et al.
patent: 4917676 (1990-04-01), Heiber et al.
patent: 5120545 (1992-06-01), Ledger
patent: 5242950 (1993-09-01), Hastings

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