Pasteurized therapeutically active protein compositions

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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424101, 424 85, 514 8, 514 21, 530381, 530382, 530383, 530386, 530393, 530830, 435188, A61K 3516, A61K 3702, A61K 3706, C07K 328

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active

046237178

ABSTRACT:
Compositions containing thermally sensitive, therapeutically active proteins are pasteurized without substantial loss of therapeutic activity by mixing the protein composition with a pasteurization-stabilizing amount of a sugar or reduced sugar and of an amino acid prior to pasteurization. Pasteurized compositions containing therapeutically active proteins, which have heretofore been unattainable, can be prepared by the method of the invention.

REFERENCES:
patent: 4061735 (1977-12-01), Funakoshi et al.
patent: 4137307 (1979-01-01), Funakoshi et al.
patent: 4279344 (1981-10-01), Schwinn
patent: 4440679 (1984-04-01), Fernandes et al.

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