Pasteurized therapeutically active blood coagulation factor conc

Details Pasteurized therapeutically active blood coagulation factor conc Pasteurized therapeutically active blood coagulation factor conc

1983-01-13

1984-09-11

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

A61K 3514

Patent

active

044709684

ABSTRACT:
Compositions containing a concentrate of coagulation Factors II, VII, IX, and X are pasteurized without substantial loss of therapeutic activity by mixing the protein composition with a pasteurization-stabilizing amount of a polyol and a source of citrate ions prior to pasteurization. Pasteurized compositions containing a concentrate of coagulation Factors II, VII, IX, and X, which have heretofore been unattainable, can be prepared by the method of the invention.

REFERENCES:
patent: 4379085 (1983-04-01), Williams et al.

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