Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1987-11-24
1989-07-18
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530389, 530427, 424 858, 424101, 424 95, C07K 300, C07K 1506
Patent
active
048495085
ABSTRACT:
Pasteurization of immunoglobulin solutions to inactivate viruses without significantly altering the IgG molecules or their physiological activities is obtained with minimal aggregation in the absence of any stabilizer by heating this solution to mildly-elevated temperatures at low ionic strength and mildly acid pH values.
REFERENCES:
patent: 3896241 (1975-07-01), Mabaspina
patent: 3930039 (1975-12-01), Kuipers
patent: 3986927 (1976-10-01), Melnick et al.
patent: 4075197 (1978-02-01), Schuck et al.
patent: 4082734 (1978-04-01), Stephan
patent: 4097473 (1978-06-01), Lewis et al.
patent: 4265924 (1981-05-01), Buhler et al.
patent: 4424206 (1984-01-01), Ohmura et al.
patent: 4440679 (1984-04-01), Fernandes et al.
patent: 4446134 (1984-05-01), Naito et al.
patent: 4623717 (1986-11-01), Fernancks et al.
patent: 4721777 (1988-01-01), Uemura et al.
Colombo M., et al., Lancet 1985; 2:1-4.
Schimpf K. et al., New England J. of Medicine, 316, 918 (1987).
Horowitz, M. S. et al., Thrombosis and Hemostasis, 58 (1) p. 371 (1987).
Pelczar M. J. et al., Microbiology, 4th Ed., McGraw-Hill, 1977, pp. 833 to 835.
Edsall, J. T., Vox Sang. 46:338-340 (1984).
Rosenqvist, E., et al., Molecular Immunology, 24, No. 5, pp. 495-501 (1987).
Christian, C. L., J. Immunology 84, 112-121.
McClelland, DBL, Yap PL, Clinics in Haematology-13, No. 1 Feb. 1984.
Bovarnick et al., J. Bacteriology 59, 509-522, 1950.
Ng, P. K. et al., Thrombosis Research 39, 439-447 (1985).
WHO/BS/83.1396-Annex 2.
Alving, B. M. et al., Immunohematherapy ed. Nydegger, Academic Press (1981).
J.A.C.S. Vol. 68, pp. 459 to 475-(1946).
Vox Sang. 7, 414 (1962).
Anderson, C. L., J. Exp. Med. 156, 1794-1806 (1982).
Molecular Immunology, 23, 331-338 (1986).
Vox Sanguinis, 50, 208 (1986).
Biochemistry Journal 118, 703, (1970).
Rousseaux-Prevost et al., Mol. Imm., 19(11), 1465-1479, (1982).
Soltis et al., Immunol., 46, 411-, (1982).
Harris et al, Vox. Sang., 36, 129-136, (1979).
Dennis Paul
Magnin Anthony A.
Wah Po-Shing
Connaught Laboratories Limited
Kushan Jeff
Moskowitz Margaret
LandOfFree
Pasteurization of immunoglobulin solutions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pasteurization of immunoglobulin solutions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pasteurization of immunoglobulin solutions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-173147