Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1994-08-22
2000-08-29
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
424832, 424 932, 536 221, 536 231, 536 237, 536 2432, 435 691, 435 693, A61K 39102, A61K 3902, C07H 1900, C07H 2104
Patent
active
061104701
ABSTRACT:
A vaccine for immunizing animals against diseases caused by microorganisms producing an osteolytic toxin comprising an immunologically effective amount of a recombinant, immunogenic, detoxified Pasteurella multocida toxin or toxin analog, the vaccine being encoded by a nucleotide sequence coding for a Pasteurella multocida toxin or toxin analog which is inserted in an expression vector capable of replicating in a suitable host microorganism in which the said sequence may be expressed. Optionally, the produced toxin or toxin analog is subjected to posttranscriptional modifications to provide the detoxified toxin or toxin analog. Alternatively, the nucleotide sequence may be modified prior to insertion into the expression vector so as to provide the toxin or toxin analog in a detoxified form. Furthermore, the use of a monoclonal antibody against Pasteurella multocida toxin or toxin analog, a labelled DNA sequence homologous to a DNA sequence coding for a toxin or toxin analog, and the toxin or toxin analog per se as diagnostic agents are described.
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International Search Report (Swedish), 2 pp.
Foged Niels Taekker
Petersen Svend
Akzo Nobel N.V.
Blackstone William M.
Devi S.
Housel James C.
Sullivan Michael G.
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