Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1993-06-10
1995-10-31
Kim, Kay K. A.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4242791, A61K 39102, A61K 3939
Patent
active
054627354
ABSTRACT:
Protection of ruminants against bacterial pneumonia caused by Pasteurella haemolytica has been achieved with a subunit vaccine. The vaccine contains two principle components; capsular polysaccharide of P. haemolytica and a synthetic adjuvant, muramyl dipeptide. This vaccine prevented bacterial infection of the lungs of vaccinated animals upon challenge with P. haemolygica. In contrast, animals that were not vaccinated or animals that were vaccinated with only capsular polysaccharide alone had severe lesions and high concentrations of P. haemolytica in the lung.
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Kim A. Brogden et al., "Effect of Muramyl Dipeptide on Immunogenicity of Corynebacterium pseudotuberculosis Whole-Cell Vaccines in Mice and Lambs," American Journal of Veterinary Research 51(2): 200-202 (Feb. 1990).
C. Adlam et al., "Capsular Polysaccharide Structures of Pasteurella haemolytica and Their Potential as Virulence Factors," In Protein-Carbohydrate Interactions in Biological Systems, pp. 391-393 Wellcome Foundation Ltd. (1986).
C. Adlam et al., "Purification, Characterization and Immunological Properties of the Serotype-Specific Capsular Polysaccharide of P. haemolytica (Serotype Al) Organisms," Journal of General Microbiology 130: 2415-2426 (1984).
Brogden Kim A.
Chedid Louis
Fado John D.
Kim Kay K. A.
Ribando Curtis P.
Silverstein M. Howard
The United States of America as represented by the Secretary of
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