Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fusion protein or fusion polypeptide
Patent
1994-06-03
1999-06-29
Mosher, Mary E.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fusion protein or fusion polypeptide
4242331, 435174, 4353171, 4352351, 530350, A61K 39385, A61K 3923, A61K 3900, C12N 1100
Patent
active
059165634
ABSTRACT:
The present invention relates to a parvovirus protein presenting capsid. Protein presenting capsid can be made by substituting nonparvovirus proteins, such as antigenic epitopes, ligands, enzymes, or peptide sequences, for the unique region of the parvovirus minor structural protein (e.g. VP1). Small regions of VP2 can also be replaced. Normal VP2 can be added to enhance capsid formation.
REFERENCES:
patent: 4971793 (1990-11-01), Wood et al.
patent: 5223424 (1993-06-01), Cochran et al.
Pintel, D. et al. 1984. Journal of Virology, vol. 52, pp. 320-327.
Labiniec-Pintel, L. et al. 1986. Journal of Virology, vol. 57, pp. 1163-1167.
Brown, C. et al. 1990. Virus Research, vol. 15, pp. 197-212.
Paradisio, P. 1982. Biological Abstracts, vol. 73, No. 3, p. 2243, abstract No. 21824.
Tattersall, P. et al. 1977. Biological Abstracts, vol. 64, No. 6, p. 3554, abstract No. 36196.
Sisk, W.P. et al. Bio/Technology, vol. 5, pp. 1077-1080, 1987.
Anderson, L.J. et al., J. Clin. Microbiol. 24:522 (1986).
Carter, B.J. et al., "Parvoviridae," In:Animal Virus Structure. Eds. Nermut and Steven, Elsevier, New York 325 (1987).
Cotmore, S.F. et al., Science 226:1161 (1984).
Kajigaya, S. et al., Proc. Natl. Acad. Sci. USA, 88:4646 (1991).
Kurtzman, G.J. et al., J. Clin. Invest. 84:1114 (1989).
Lebkowski, J.S. et al., Mol. Cell. Biol. 8:3988 (1988).
Malcolm, B.A. et al., Proc. Natl. Acad. Sci. USA, 86:133 (1989).
McLaughlin, S.K. et al., J. Virol. 62:1963 (1988).
Newman, M.A. et al., J. Immunol. 149:3260 (1992).
Ozawa, K. et al., J. Virol. 61:2627 (1987).
Ozawa, K. et al., J. Virol. 62:2884 (1988).
Ozawa, K. et al., Science 233:883 (1986).
Ozawa, K. et al., J. Virol. 61;2395 (1987).
Shimada, T. et al., Molec. Cell. Biol. 7:2830 (1987).
Smith-Gill, S.J. et al., J. Immunol., 128:314 (1982).
Takahashi, T. et al., J. Inf. Dis. 160:548 (1989).
Wong, S. et al., J. Virol., 68:4690 (1994).
Yaegashi, N. et al., J. Virol. 63:2422 (1989).
Young, N. et al., J. Clin. Invest. 74:2024 (1984).
Agbandje, M. et al., "The Structure of Human Parvovirus B19 at 8 .ANG. Resolution." The 203:106 (1994).
Bansal, G.P. et al., "Candidate Recombinant Vaccine for Human B19 Parvovirus." The Journal of Infectious Disease 167: 1034 (1993).
Miyamura, K. et al., "Parvovirus particles as platforms for protein presentation." Proc. Natl. Acad. Sci. USA 91:8507 (1994).
Saikawa, T. et al., "Neutralizing Linear Epitodes of B19 Parvovirus Cluster in the VP1 Unique and VP-VP2 Junction Regions." Journal of Virology 67:3004 (1993).
Kajigaya Sachiko
Takashi Shimada
Young Neal S.
Mosher Mary E.
United States of America
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