Parvovirus NS1 variants

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...

Reexamination Certificate

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Details

C435S320100, C435S325000, C435S069100, C435S069300, C435S005000, C536S023720

Reexamination Certificate

active

06919196

ABSTRACT:
The present invention relates to a parvovirus NS1 variant having a shifted equilibrium between the DNA replication and transcription activities (a) and the cytotoxicity activity (b). Furthermore, this invention relates to DNAs coding for these parvovirus NS1 variants and methods of producing them. Additionally, this invention concerns antibodies directed against the parvovirus NS1 variants as well as the use of the DNAs and the parvovirus NS1 variants.

REFERENCES:
Nuesch et al (Journal of Virology 72:8002-8012, Oct. 1998).
Nuesch et al (Journal of Virology 72:9966-9977, Dec. 1998).
Legender et al (Journal of Virology 66:5705-5713, 1992).
Yeung et al (Virology 181:35-45, 1991).
Moffatt et al (Journal of Virology 72:3018-3028, Apr. 1998).
XP-000867510. Legendre et al. “Terminal Regions of the NS-1 Protein of the parvovirus Minute Virus of Mice Are Involved in Cytotoxicity and Promoter trans inhibition.” Jour. Of Virol. Oct. 1992. p. 5705-5713.
XP-000867496. Li et al. “Mutation of Lysin 405 to Serine in the Parvovirus H-1 NS1 Abolishes Its Functions for Viral DNA Replication Late Promoter trans Activation, and Cytotoxicity.” Jour. Of Vir. Oct. 1990. p. 4654-4660.
XP-002088311. Nuesch et al. “Sequence Motifs in the Replicator Protein of Parvovirus MVM Essential for Nicking and Vocalent Attachment to the Viral Origin: Identification of the Linking Tyrosine.” Nuesch et al. Virol. 209, 122-135 (1995).
XP-002088309. Cotmore et al. “The NS1 Polypeptide of the Murine Parvovirus Minute Virus of Mice Binds to DNA Sequences Containing the Motif [ACCA]2-3.” Jour of Virol. Mar. 1995, p. 1652-1660.

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