Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Reexamination Certificate
2005-07-19
2005-07-19
Mosher, Mary E. (Department: 1648)
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
C435S320100, C435S325000, C435S069100, C435S069300, C435S005000, C536S023720
Reexamination Certificate
active
06919196
ABSTRACT:
The present invention relates to a parvovirus NS1 variant having a shifted equilibrium between the DNA replication and transcription activities (a) and the cytotoxicity activity (b). Furthermore, this invention relates to DNAs coding for these parvovirus NS1 variants and methods of producing them. Additionally, this invention concerns antibodies directed against the parvovirus NS1 variants as well as the use of the DNAs and the parvovirus NS1 variants.
REFERENCES:
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Moffatt et al (Journal of Virology 72:3018-3028, Apr. 1998).
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XP-002088311. Nuesch et al. “Sequence Motifs in the Replicator Protein of Parvovirus MVM Essential for Nicking and Vocalent Attachment to the Viral Origin: Identification of the Linking Tyrosine.” Nuesch et al. Virol. 209, 122-135 (1995).
XP-002088309. Cotmore et al. “The NS1 Polypeptide of the Murine Parvovirus Minute Virus of Mice Binds to DNA Sequences Containing the Motif [ACCA]2-3.” Jour of Virol. Mar. 1995, p. 1652-1660.
Nüesch Jürg
Rommelaere Jean
Deutsches Krabsforschungzentrum Stiftung Des Offentlichen Rechts
Fuierer Marianne
Fuierer Tristan Anne
Hultquist Steven J.
Mosher Mary E.
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