Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1993-03-22
1995-09-12
Parr, Margaret
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
4352351, 435 5, G01N 33569, C12N 700, C12Q 170
Patent
active
054496080
ABSTRACT:
The invention provides a method of detecting the presence of a parvovirus in a sample comprising contacting the sample with a purified receptor for a parvovirus, and detecting the presence of binding of parvovirus to the receptor, the presence of binding indicating the presence of parvovirus in the sample. The present invention also provides methods of purifying and removing parvoviruses from samples. The invention further provides a composition comprising a globoside, or the parvovirus B19 binding domain of globoside, in a pharmaceutically acceptable carrier. Also provided are methods of preventing or treating parvovirus B19 infection in a human subject by preventing the binding of parvovirus B19 to P antigen and methods of gene therapy utilizing parvovirus B19 and the parvovirus B19 cellular receptor.
REFERENCES:
Brown, K. E. & Cohen, B. J., J. Gen. Virol., 73:2147-2149 (1992).
Yoshimoto, Kohji et al., "A Second Neutralizing Epitope of B19 Parvovirus Implicates the Spike Region in the Immune Response," Journal of Virology, 65(12):7056-7060 (Dec. 1991).
Sato, Hiroyuki et al., "Identification of the Region Including the Epitope for a Monoclonal Antibody Which Can Neutralize Human Parvovirus B19," Journal of Virology, 65(4):1667-1672 (Apr. 1991).
Young, N., Semin. Hematol., 25:159-172 (1988).
von dem Borne, A. E., Bos, M. J., Joustra-Maas, N., et al., Br J Haematol., 63:35-46 (1986).
Brown Kevin E.
Young Neal S.
Parr Margaret
Schreiber David
The United States of America as represented by the Department of
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