Partricin derivatives in the prophylactic and/or curative treatm

Details Partricin derivatives in the prophylactic and/or curative treatm Partricin derivatives in the prophylactic and/or curative treatm

1997-10-14

1999-06-01

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

A61K 3170

Patent

active

059088346

ABSTRACT:
The use of ester and/or amide derivatives of partricin A and/or B to inhibit or forestall the growth of yeasts and molds in cell cultures of animal or vegetable origin, including hybridomas and cells whose DNA was modified. This use consists in adding the afore-said derivatives to the cell cultures in concentrations such as to inhibit the growth of yeast and molds but such as not to be toxic for the cell cultures themselves. The invention can be made use of, for instance, in the production of vaccines and in the conservation of organs and tissues intended for transplantation.

REFERENCES:
patent: 3780173 (1973-12-01), Bruzzese et al.
patent: 3961047 (1976-06-01), Bruzzese et al.
patent: 5296597 (1994-03-01), Bruzzese et al.
patent: 5298495 (1994-03-01), Bruzzese et al.
Samson Wright's Applied Physiology, Eleventh Ed., C.A. Keele, Ed., Oxford Univ. Press, London, p. 64, 1965.
P.B. Weisz, The Science of Biology, McGraw-Hill, New York, pp. 439-440, 1959.
T. Bruzzese et al, Eur. J. Med. Chem., vol. 31, pp. 965 and 972 (1996).

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