Partricin derivatives

Details Partricin derivatives Partricin derivatives

1991-12-03

1994-03-29

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 65, A61K 3170, C07H 1708

Patent

active

052984958

ABSTRACT:
Derivatives of partricin and of its individual components, partricin A and B, wherein the mycosamine primary amino group forms an amide bond with the carboxy group of acids containing in addition a basic nitrogen group, the carboxy group at C-18 of macrolide ring being either free or in form of ester or neutral amide or containing in the chain a basic nitrogen moiety, their pharmaceutically acceptable salts, a process for preparing the same and pharmaceutical formulations containing the same.

REFERENCES:
patent: 3961047 (1976-06-01), Bruzzese et al.
patent: 4783527 (1988-11-01), Falkowski et al.
J. J. Kim Wright et al., N-Aminoacyl Derivatives of Polyene Macrolide Antibiotics and their Esters, vol. 35, No. 7, Journal of Antibiotics, Jul. 1982, pp. 911-914, Tokyo, JP.
R. C. Tweit, Characterization of the Antifungal and Antiprotozoal Antibiotic Partricin and Structural Studies on Partricins A and B, vol. 35, No. 8, Journal of Antibiotics, Aug. 1982, pp. 997-1005, Tokyo, JP.
J. Golik et al., The Structure of Mepartricin A and Mepartricin B, vol. 33, No. 8, Aug. 1980, pp. 904-907, Tokyo, JP.

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