Partitioning of polymorphic DNAs

Details Partitioning of polymorphic DNAs Partitioning of polymorphic DNAs

1998-07-09

2000-06-13

Elliott, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 231, 536 2433, 345440, 436173, 435 911, C12Q 168, G06T 1100, C12P 1934, C07H 2100

Patent

active

060748311

ABSTRACT:
Methods for applying graph theory techniques in methods to establish multiplexed assay formats for analyzing polymorphic DNAs are provided. These methods are used for designing and carrying out rapid and efficient processes for distinguishing target polymorphic DNA segments on the basis of variations in sequence and/or length. The methods are thus useful in the design of assays for determining identity, ancestry, predisposition to disease, or the presence or absence of a desired trait; genetic linkage analyses (gene mapping); and drug development.

REFERENCES:
patent: 5667970 (1997-09-01), Zhang
patent: 5841958 (1998-11-01), Buss et al.
patent: 5885775 (1999-03-01), Haff et al.
Hall et al., "An Approach to High-Throughput Genotyping," Genome Research review:781-790 (1996).
Perlin et al., "Toward Fully Automated Genotyping: Genotyuping Microsatellite Markers by Deconvolution," Am. J. Hum. Genet. 57:1199-1210 (1995).

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