Particulate NMR contrast agents for gastrointestinal application

Details Particulate NMR contrast agents for gastrointestinal application Particulate NMR contrast agents for gastrointestinal application

1983-11-14

1986-10-07

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

128653, 128654, 424 4, 436173, 436806, A61K 4900, A61B 505, A61B 600

Patent

active

046158790

ABSTRACT:
Contrast media compositions for nuclear magnetic resonance (NMR) imaging of the gastrointestinal system are provided for oral or rectal administration. The compositions comprise aqueous suspensions of particles of an NMR contrast agent, the particles being very finely-divided and providing in their outer surfaces a substantially water-insoluble paramagnetic compound. Suspending and/or wetting agents may be included to maintain the contrast agent particles in a dispersed, suspended condition for the oral or rectal administration. Buffering agents may also be included to maintain the pH of the suspension in a pH range protecting the insolubility of the paramagnetic compound.

REFERENCES:
patent: 4352751 (1982-10-01), Wieder et al.
Runge et al., Radiology, vol. 147, (1983), pp. 789-791.
Wesbey et al., Radiology, vol. 149, (1983), pp. 175-180.
U.S.P. XVI, (The United States Pharmacopeia), 1960, pp. 1072-1073.
Young et al., CT, 5:543-546 (1981).
U.S.P. XX, p. 1105.
Newhouse et al., Radiology, 142:246 (1982).
Mansfield and Morris, "NMR Imaging in Biomedicine", Supp. 2, Chap. 7, pp. 217-245; and Notes Added in Proof (1982, Academic Press).

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