Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1987-10-26
1990-04-17
Nucker, Christine M.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
424 89, 530395, 530403, 530806, 530812, 530824, 530826, 435 5, C07K 1504, C07K 1514, C07K 1700, G01N 33569
Patent
active
049181661
ABSTRACT:
Fusion proteins comprise a77 first amino acid sequence and a second amino acid sequence. The first amino acid sequence is derived from a retrotransposon or an RNA retrovirus and confers on the fusion protein the ability to assemble into particles; an example is the product of the YTA gene of the yeast retrotransposon Ty. The second amino acid sequence is an HIV antigen. So particles formed of the fusion proteins may be useful in vaccines or in diagnostic or purification applications.
REFERENCES:
patent: 4722840 (1988-02-01), Valenzuela et al.
Wilson et al., "Expression Strategies of the Yeast Retrotransposon Ty: A Short Sequence Directs Ribosomal Frameshifting", Nucl. Acids Res., 14 (1986), 7001-7016.
Putney et al., "HTLV-III/LAV-Neutralizing Antibodies to an E. Coli-Produced Fragment of the Virus Envelope", Science, 234 (1986), 1392-1395.
Lasky et al., "Neutralization of the Aids Retrovirus by Antibodies to a Recombinant Envelope Glycoprotein", Science, 233 (1986), 209-212.
Dobson et al., "The Identification and High Level Expression of a Protein Encoded by the Yeast Ty Element", Embo J., 3 (1984), 1115-1119.
Malim et al., "The Production of Hybrid Ty:IFN Virus-Like Particles in Yeast", Nucl. Acids Res., 15 (1987), 7571-7580.
Fulton et al., "Variants Within the Yeast Ty Sequence Family Encode a Class of Structurally Conserved Proteins", Nucl. Acids Res., 13 (1985), 4097-4112.
Mellor et al., "Reverse Transcriptase Activity and Ty RNA are Associated with Virus-Like Particles in Yeast", Nature, 318 (1985), 583-586.
Mellor et al., "A Retrovirus-Like Strategy for Expression of a Fusion Protein Encoded by Yeast Transposon Ty 1", Nature, 313 (1985), 243-246.
Adams Sally E.
Kingsman Alan J.
Kingsman Susan M.
Nucker Christine M.
Oxford Gene Systems Limited
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