Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1984-10-05
1988-11-08
Brown, J. R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514858, A61K 3124
Patent
active
047834846
ABSTRACT:
A pharmaceutical composition combines a physiologically acceptable carrier with substantially uniformly sized particles of an organoiodide or organobromide which is solid at physiological tempertures, has a solubility in blood serum of less that one part per ten thousand, and has a mean particle diameter of from about 0.01 microns to about 4 microns. The method of the invention involves administering to a patient an effective amount of such particles.
REFERENCES:
patent: 2776241 (1957-01-01), Priewe
patent: 2861024 (1958-11-01), Silver
patent: 2919181 (1959-12-01), Reinhardt
patent: 3489686 (1970-01-01), Parran
patent: 3580853 (1971-05-01), Parran
patent: 3663685 (1972-05-01), Evans
patent: 3723325 (1973-03-01), Parran
patent: 3753916 (1973-08-01), Parran
patent: 3761417 (1973-09-01), Parran
patent: 3761418 (1973-09-01), Parran
patent: 3875071 (1975-04-01), Grand
patent: 3892800 (1975-07-01), Nickel et al.
patent: 3919190 (1975-11-01), Barker et al.
patent: 3957741 (1976-05-01), Rembaum et al.
patent: 4005188 (1977-01-01), Tilly et al.
patent: 4009232 (1977-02-01), Skiiki et al.
patent: 4059624 (1977-11-01), Harrison
patent: 4105598 (1978-08-01), Yen et al.
patent: 4180619 (1979-12-01), Makhlouf et al.
patent: 4234600 (1980-11-01), Sirrenberg et al.
patent: 4395391 (1983-07-01), Pfeiffer
patent: 4406878 (1983-09-01), DeBoer
Klebanoff, "Iodination with bacteria: a bacterial mechanism", J. Exp. Med. 126: 1063-78 (1967).
Klebanoff, "Myeloperoxidase-halide-hydrogen peroxide antibacterial System," J. Bacteriol., 95:2131 (1968).
Woeber et al., "Stimulation by phagocytosis of the deiodination of L-thyroxine in human leukocytes," Science, 176:1039 (1972).
Steigbigel et al., "Phagocytic and bactericidal properties of normal human monocytes" J. Clin. Invest., 53:131 (1974).
DeChatelet et al., "Effect of phorbol myristate acetate on the oxidative metabolism of human polymorphonuclear leukocytes," Blood, 47:545 (1976).
Violante et al., "Particulate contrast media," Invest. Radiol, 15:S329 (1980).
Violante et al., "Biodistribution of a particulate hepatolienographic CT contrast agent: A study of iodipamide ethyl ester in the rat," Invest. Radiol., 16:40 (1981).
Lauteala et al. "Effect of intraveously administered iodipamide ethyl ester particles on rat liver morphology," Inv. Radiol. 19:133 (Mar.-Apr. 1984).
Violante et al., "Protein Binding to Iothalamate Ethyl Ester," Inv. Radiol. 14:177 (1979).
Violante et al., "Maximizing hepatic contrast enhancement with a particulate contrast agent in computed tomography." (Excerpta Medica 1981).
Violante and Fischer, "Particulate Suspensions as Contrast Media," ch. 13 in Handbook of Experimental Pharmacology, vol. 73, Sovak, ed. (Springer Berlin 1984).
Grimes et al., "Formulation and Evolution of Ethiodized Oil Emulsion for Intravenous Hepatography," J. Pharmaceut. Sci. 68:52 (1979).
Fischer, "Improvement in radiographic contrast media through the development of colloidal or particulate media: An analysis," J. Theor. Biol. 67: 653-670 (1977).
Violante et al., "Particulate contrast media for computed tomographic scanning of the liver," Inv. Radiol. 15: S171 (1980).
Pullman, Violante, and Steigbigel, "Enhancement of Phagocyte Intracellular (ic) Killing by Iodipamide Ethyl Ester", Abstract, ASM Meeting, Oct. 8, 1984.
Violante et al. "Protein Binding to Iothalamate Ethyl Ester" Inv. Radiol. 14:177 (1979).
Klebanoff, J. Bacteriol, 95:2131, 1968.
Woeber et al Science, 176:1039, 1972.
Steigbigel et al., J. Clin. Invest., 53:131, 1974.
Dechatelet et al., Blood, 47:545, 1976.
Violante et al., Invest Radiol., 15: S329. 1980.
Violante et al., Invest Radiol., 16:40, 1981.
Steigbigel Roy T.
Violante Michael R.
Brown J. R.
Rollins Jr. John W.
University of Rochester
LandOfFree
Particulate composition and use thereof as antimicrobial agent does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Particulate composition and use thereof as antimicrobial agent, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Particulate composition and use thereof as antimicrobial agent will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-464319