Particulate adsorbent for the removal of biomacromolecules such

Details Particulate adsorbent for the removal of biomacromolecules such Particulate adsorbent for the removal of biomacromolecules such

1993-09-28

1995-12-19

Nakarani, D. S.

Stock material or miscellaneous articles

Coated or structually defined flake, particle, cell, strand,...

Particulate matter

428402, 604 5, B32B 2730

Patent

active

054767156

ABSTRACT:
A material for the elimination of biomacromolecules, in particular LDL and endotoxins from a whole blood circuit, comprising an adsorbent, comprising a porous carrier material of a homo-, co-, or terpolymer of acrylic acid and/or methacrylic acid with a particle range of between 50 and 250 .mu.m, an exclusion level of at least 5.times.10.sup.5 daltons, as well as organic ligands which are covalently bound to the carrier material via a spacer, wherein the carrier material has a spherical shape and suitably, the spacer contains no double bonds.

REFERENCES:
"Immobilization of Proteins on TOYOPEARL gels", Hagi et al, pp. 13-21, Feb. 1981.
"Fractogel TSK for Gel Chromatography, ion Exchange Chromatograph and Affinity Chromatography--Operating ranges and new modifications", W. G. Dorner, Inzell GIT Fachz. Lab 27 (1983) 380-389, May 1983.
Jour. of Chromatography, 239 (1982) 747-754.
2nd. Soor-Lor-Lux-Meeting on Advanced Materials and Nono-Composite Techniques (Oct. 1992).
Lipid Apheresis by Hemoperfusion: In-Vitro Efficacy and Ex-Vivo Bio-Compatibility of a New LDL Adsorber Compitable with Human Whole Blood, Sep. 1993.
European Search Report EP 90 11 8896, Feb. 13, 1991.

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