Particles of hydrophobic or sparingly soluble substance

Details Particles of hydrophobic or sparingly soluble substance Particles of hydrophobic or sparingly soluble substance

1988-11-02

1992-10-27

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424491, 424493, 424496, 424497, A61K 914, A61K 3143

Patent

active

051587793

ABSTRACT:
The surface of micronized and hydrophilized powder particles of a hydrophobic or sparingly soluble substance is covered with a cohesive layer of not more than 0.1 part by weight of surfactant in not more than 10 parts by weight of a binder (based on 100 parts by weight of the substance). A sparingly soluble or insoluble antibiotic is converted to instant granules or instant tablets, while a hydrophobic, moderately soluble to readily soluble pharmaceutical substance, such as, for example, acetylsalicylic acid or paracetamol, is converted to effervescent granules or effervescent tablets. The particles are preferably applied to carbohydrate crystals by means of a binder. The preparation is carried out by a method in which a solution which contains at least one surfactant in an amount of 0.01 to 0.1% by weight, based on the weight of the particles to be hydrophilized, and a binder in an amount corresponding to 5 to 10 times the weight of the surfactant used is sucked through a bed of the particles under a pressure of less than 800, preferably less than 100, mbar.

REFERENCES:
patent: 3887700 (1975-06-01), Bonsey et al.
patent: 3920442 (1975-11-01), Albert et al.
patent: 4344934 (1982-08-01), Martin et al.
O. A. Neumuller, "Romps Chemie-Lexikon," 7th Ed., vol. 5, p. 3083 (1975).

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