Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Biocides; animal or insect repellents or attractants
Patent
1998-07-01
2000-10-17
Dees, Jose' G.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Biocides; animal or insect repellents or attractants
424401, 424449, 424489, 514963, 264 43, 264 432, 264 47, 42840224, A61K 700
Patent
active
061327506
ABSTRACT:
The invention relates to small sized particles.
These particles comprise at least on the surface thereof a wall composed of a mixture of at least one protein and at least one polysaccharide which are cross-linked, preferably by interfacial cross-linking with a polyfunctional acylating agent which forms at least amide and ester bonds, and optionally anhydride bonds with amine, hydroxyl or carboxyl functions of the protein and of the polysaccharide, and which comprise hydroxamic groups on the surface thereof for chelating metal ions.
These particles can be used in cosmetics or in pharmacy notably for the chelation or release of metal ions.
REFERENCES:
patent: 5395620 (1995-03-01), Huc et al.
Hettler D. et al.--"Polyhydroxamic Microcapsules Prepared From Proteins: A Novel Type Of Chelating Microcapsules" Journal of Microencapsulation, vol. II, No. 2, 1 mars 1994, pp. 213-224.
Levy, M.C. et al.--"Polyhydroxamic Serum Albumin Microcapsules: Preparation And Chelating Properties"--International Journal of Pharmaceutics, vol. 69, 1991, pp. R1-R4.
Levy, M.C. et al.--"Mixed-Walled Microcapsules Made Of Cross-Linked Proteins and Polysaccharides: Preparation And Properties"--Journal of Microencapsulation, vol. 8, No. 3, 1 juillet 1991, pp. 335-347.
Rongved Pal et al.--"Cross-Linked, Degradable Starch Microspheres As Carriers Of Parmagnetic Contrast Agents For Magnetic Resonance Imaging: Synthesis, Degradation, And Relaxation Properties"--Carbohydrate Research, vol. 214, 1991, pp. 325-330
J. Med. Chem. 1981, 24, 1263-1266, Margel, "A Novel Approach for Heavy Metal Poisoning Treatment, a Model, Mercury Poisoning by means of Chelating Microspheres: Hemoperfusion and Oral Administration".
J. Nuclear Med. 22, 623-626, 1981, Hnatovitch et al., "Albumin Microspheres Labeled with Ga-67 by Chelation: Concise Communication".
Magnetic Resonance Quarterly, 6, 65-84, 1990, Lauffer, "Magnetic Resonance Contrase Media: Principles and Progress".
Carbohydrate Res. 214, 325-330, 1991, Rongved et al., "Cross-linked, degradable starch microspheres as carriers of paramagnetic contrast agents for magnetic resonance imaging: Synthesis, degradation, and relaxation properties".
J. Microencapsulation, 1994, vol. 11, No. 2, pp. 213-224, Hettler et al., "Polyhydroxamic microcapsules prepared from proteins: a novel type of chelating microcapsules".
Bonnet Isabelle
Buffevant Chantal
Levy Marie-Christine
Perrier Eric
Coletica
Dees Jos,e G.
Williamson Michael A.
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