Particles for immunoassays and methods for treating the same

Details Particles for immunoassays and methods for treating the same Particles for immunoassays and methods for treating the same

2005-05-10

2005-05-10

Ceperley, Mary E. (Department: 1641)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is organic

C436S524000, C436S525000, C436S527000, C436S825000, C436S826000, C436S909000

Reexamination Certificate

active

06890765

ABSTRACT:
A method of treating particles to be used in immunoassays reduces interference in particle agglutination assays. For particles having covalently bound antibodies and residual NHS-ester or sNHS-ester groups on the surface, the reactive esters are treated with an aqueous mixture containing an amine compound of formula (I):in-line-formulae description="In-line Formulae" end="lead"?H2N—R—X  (I).in-line-formulae description="In-line Formulae" end="tail"?The moiety —X is —NH2, —OH, or —CO2CH2CH3; and R is an alkyl group or an alkyl ether group. When —X is —NH2or —CO2CH2CH3, R contains from 1 to 20 carbon atoms; and when —X is —OH, R contains from 4 to 20 carbon atoms.

REFERENCES:
patent: 4292038 (1981-09-01), Kondo et al.
patent: 4362531 (1982-12-01), de Steenwinkel et al.
patent: 4536478 (1985-08-01), Sokoloff et al.
patent: 5486479 (1996-01-01), Ito et al.
patent: 5506151 (1996-04-01), Ito et al.
patent: 5643732 (1997-07-01), Strahilevitz
patent: 5846751 (1998-12-01), Pronovost et al.
patent: 6030845 (2000-02-01), Yamao et al.
patent: 6203706 (2001-03-01), Schwind et al.
patent: 6274325 (2001-08-01), Deger et al.
patent: 0 679 892 (1995-11-01), None
patent: WO 9706166 (1997-02-01), None
patent: WO 9836277 (1998-08-01), None
patent: WO 0203068 (2002-01-01), None
M. Dijksma et al, Anal. Chem. 73(5), 901-907 (Jan. 27, 2001).*
T.J. Inzana, J. Clin. Microbiol., 33, 2297-2303 (1995).*
European Search Report from corresponding European Application No. 02 02 4080, dated May 7, 2003, 4 pages.*
J.L. Ortega-Vinuesa et al.J. Biomater. Sci. Polymer Edn., 12(4), 379-408 (2001).
C.R. Martin et al.Analytical Chemistry—News&Features, May 1, 1998, 322A-327A.
R.G. Chapman et al.J. Am. Chem. Soc., 122, 8303-8304 (2000).
N. Nakajima and Y. Ikada,Bioconjugate Chem., 6, 123-130, (1995).
M. Yamaguchi et al.J. Health Science, 47(4), 419-423 (2001).
S. Perez-Amodio et al.Anal. Chem., 73, 3417-3425 (2001).
P. Holownia et al.Anal. Chem., 73, 3426-3431 (2001).
A. Singh et al.J. Biosci., 25(1), 47-54 (2000).
J. Sackrison, “Covalent Coupling And Diagnostic Development Using Microspheres”, 17 pages (1996).
Bangs Laboratories, Inc., Tech Note #13c—“Covalent Coupling Protocols”, 9 pages.

Affiliated with

Also associated with

Rating

Particles for immunoassays and methods for treating the same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Particles for immunoassays and methods for treating the same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Particles for immunoassays and methods for treating the same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3463199