Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1996-05-28
1998-02-17
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424483, 424490, 424 781, A61K 914
Patent
active
057189200
DESCRIPTION:
BRIEF SUMMARY
This application is a 371 of PCT/NL93/00252 filed Nov. 29, 1993.
The present invention relates to particles for binding monovalent valent cations, which particles are generally in the form of microcapsules.
In several situations it is desired to lower the amounts of monovalent cations being present in products such as foodstuff or food additives destinated to be consumed by humans or animals. E.g. in EP-B-0150574 it is stated that it is well-known that one of the contributory factors to hypertension end some other diseases is the excessive ingestion of salt, i.e. sodium chloride. This makes circumvention/prevention of sodium in foods a most important and effective dietetic care for patients suffering from hypertension or renal troubles and those who wish to prevent these diseases. So far these people have been forced to take an unpalatable prescribed diet of an extremely low salty taste. The sodium content of certain foodstuffs can also be reduced by adding a desalinating agent such as an ion exchange resin to the food prior to consumption. This method also results in a low salty taste. Another method for the medical treatment of such a patient is to administrate the patient, preferably after consumption of sodium, a desalinating agent capable of absorbing an excess of sodium ions which may be an acidic ion exchange resin or a weakly acidic ion exchange resin in the potassium form or, in the hydrogen form with the object of removing or mitigating the adverse influences caused by the sodium ions when the patient takes an ordinary meal containing salt in order to give it an acceptable taste. These ion exchange resins are of course inherently not edible and extremely unpalatable for the patients, but also toxic since the resin binds bivalent ions and also other essential compounds. Accordingly, it has been eagerly desired to develop a desalinating agent which in itself is a food ingredient of good palatability end not harmful to humans and animals.
The invention of EP-B-0150574 relates to the use of marine algae as desalinating agents. These materials should, however, be used in relatively large amounts. For instance, for each g of sodium chloride an amount of at least about 20 g of marine algae is needed. The algae material is viscous and bulky since it will be saturated with water, several fold in weight compared to its own weight. Furthermore, the marine algae product is not a reliable desalinating agent in view of lacking stability in the digestive tract. A further disadvantage is that salt will be instantaneously absorbed, which has an adverse effect on the taste. Furthermore bivalent cations will be bound and removed from the body which might lead to mineral exhaustion (depletion).
A method for reducing the salt content of foodstuff solutions and suspensions is described in CH-003158. In this document an ion exchange resin is present in a permeable sachet, made of natural or synthetic fiber sheet, filter paper, porous plastics or perforated metal sheet. Preferably the exchange resin contains calcium, potassium or ammonium ions and the sachet is only half-filled. These sachets are used for reducing the sodium content of soups in special diets. It will be clear that the taste effect of sodium chloride is lost before the soups are consumed.
It is an object of the present invention to provide a material or composition capable of efficiently binding monovalent cations such as sodium ions without the disadvantages of the known materials as discussed in the above.
Additional objects, advantages and novel features of the present invention are set forth in the description that follows, and in part will become apparent to those skilled in the art upon examination of the following description or may be learnt by practice of the invention.
To achieve the foregoing object and in accordance with the purpose of the present invention, as embodied and broadly described herein, there is provided a material consisting of particles for binding monovalent cations, in particular microcapsules, comprising in particular sodium
REFERENCES:
patent: 4042496 (1977-08-01), Tsushima et al.
patent: 4118336 (1978-10-01), Morishita et al.
patent: 4123381 (1978-10-01), Morishita et al.
Benston, Jr. William E.
Page Thurman K.
Salternate B.V.
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