Particles based on polyamino acid(s) and capable of being used a

Details Particles based on polyamino acid(s) and capable of being used a Particles based on polyamino acid(s) and capable of being used a

1996-03-25

1999-05-18

Richter, Johann

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424491, 424401, 514 12, 514 21, A61K9/14

Patent

active

059049367

ABSTRACT:
The present invention relates to delivery vehicles which are useful for the administration of active principles (APs), preferably medicinal or nutritional active principles, in particular via the oral or parenteral route.
The technical problem solved by the invention is that which consists in providing delivery vehicles composed of (nano)- or (micro)particles based on polyamino acids, and which are invert with respect to the AP (proteins), of controllable particle size, strong and inexpensive.
According to the invention, the particles have an average size of less than 200 .mu.m and consist of a polyamino acid of the Leu/Glu type, in which Leu/Glu+Leu.gtoreq.3% and the M.sub.w .gtoreq.4,000 D.

REFERENCES:
patent: 4351337 (1982-09-01), Sidman
patent: 4976968 (1990-12-01), Steiner
Kreuter, Pharm. Acta. Helv., 58, 7, 1983 CH, 196-209. (1983).

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