Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2003-07-02
2008-11-11
Crouch, Deborah (Department: 1632)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C435S320100, C435S459000
Reexamination Certificate
active
07449449
ABSTRACT:
A method of transferring a gene to vertebrate cells is disclosed. The method comprises the steps of: (a) providing microprojectiles, the microprojectiles carrying polynucleic acid sequences, the sequences comprising, in the 5′ to 3′ direction, a regulatory sequence operable in the tissue cells and a gene positioned downstream of the regulatory sequence and under the transcriptional control thereof; and (b) accelerating the microprojectiles at the cells, with the microprojectiles contacting the cells at a speed sufficient to penetrate the cells and deposit the polynucleic acid sequences therein. Preferably, the target cells reside in situ in the animal subject when they are transformed. Preferred target cells are dermis or hypodermis cells, and preferred genes for insertion into the target cells are genes which code for proteins or peptides which produce a physiological response in the animal subject.
REFERENCES:
patent: 3931397 (1976-01-01), Harnden
patent: 4224404 (1980-09-01), Viza et al.
patent: 4394448 (1983-07-01), Szoka, Jr. et al.
patent: 4689320 (1987-08-01), Kaji
patent: 4699880 (1987-10-01), Goldstein
patent: 4704692 (1987-11-01), Ladner
patent: 4738927 (1988-04-01), Taniguchi et al.
patent: 4761375 (1988-08-01), Clark
patent: 4798786 (1989-01-01), Tice et al.
patent: 4806463 (1989-02-01), Goodchild et al.
patent: 4870009 (1989-09-01), Evans et al.
patent: 4944942 (1990-07-01), Brown et al.
patent: 4945050 (1990-07-01), Sanford et al.
patent: 5100792 (1992-03-01), Sanford et al.
patent: 5204253 (1993-04-01), Sanford et al.
patent: 5589466 (1996-12-01), Felgner et al.
patent: 5703057 (1997-12-01), Johnston et al.
patent: 6194389 (2001-02-01), Johnston et al.
patent: 0 270 356 (1988-06-01), None
patent: 0 301 749 (1989-02-01), None
patent: 0 465 529 (1992-01-01), None
patent: 7781 (1970-03-01), None
patent: 86/00930 (1986-02-01), None
patent: 91/00359 (1991-01-01), None
patent: 91/07487 (1991-05-01), None
patent: 95/05853 (1995-03-01), None
patent: 97/19675 (1997-06-01), None
patent: 97/37966 (1997-10-01), None
S. Akhtar, et al., “Anti-HIV therapy with antisense oligonucleotides and ribozymes: realistic approaches or expensive myths,” 38 Journal of Antimicrobial Chemotherapy 159-165 (1996).
M. Böttger, et al., “Condensation of vector DNA by the chromosomal protein HMG1 results in efficient transfection,” 950 Biochimica et Biophysica 221-228 (1988).
J. Boynton, et al., “Chloroplast Transformation in Chamydomonas with High Velocity Microprojectiles,” 240 Science 1534-1538 (Jun. 10, 1988).
A. Branch, “A good antisense molecule is hard to find,” 23 TIBS 45-50 (Feb. 1998).
R. A. F. Clark, “Overview and General Considerations of Wound Repair,” The Molecular and Cellular Biology of Wound Repair 3-33 (1998).
S.T. Crooke “Basic Principles of Antisense Therapeutics,” 131(12) Handbook of Experimental Pharmacology 1-50 (1997).
J. J. Donnelly, et al., “DNA Vaccines,” 15 Annual Review Immunology 617-648 (1997).
M. D. Eisenbraun, et al., “Examination of Parameters Affecting the Elicitation of Humoral Immune Responses by Particle Bombardment-Mediated Genetic Immunization,” 12(9) DNA and Cell Biology 791-797 (1993).
P. T. C. Ho, et al., “Antisense Oligonucleotides as Therapeutics for Malignant Diseases,” 24(2) Seminars in Oncology 187-202 (Apr. 1997).
J. L. Jainchill, et al., “Murine Sarcoma and Leukemia Viruses: Assay Using Clonal Lines of Contact-Inhibited Mouse Cells,” 4(5) Journal of Virology 549-553 (1969).
S. A. Johnston, et al., “Gene Gun Transfection of Animal Cells and Genetic Immunization,” 43 Methods in Cell Biology 353-365 (1994).
E. T. Keller, et al., “In vivoparticle-mediated cytokine gene transfer into canine oral mucosa and epidermis,” 3(3) Cancer Gene Therapy 186-191 (1996).
T. M. Klein, et al., “Factors Influencing Gene Delivery into Zea Mays Cells by High-Velocity Microprojectiles,” 6 Bio/Technology 559-563 (May 1988).
C. M. Nicolet, et al., “Expression of a tumor-reactive antibody-interleukin 2 fusion protein afterin vivoparticle-mediated gene delivery,” 2(3) Cancer Gene Therapy 161-170 (1995).
L. E. Rosenberg, et al., “Gene Therapist, Heal Thyself.” 287 Science (Mar. 10, 2000).
J. C. Sanford, “The biolistic process,” 6 TIBTECH Reviews 299-302 (Dec. 1988).
R. W. Wilfred, et al., “Counterion-Induced Condensation of Deoxyribonucleic Acid. A Light-Scattering Study,” 18(11) American Chemical Society Biochemistry 2192-2196 (1979).
Beddow Particulate science and technology pp. 3-37, vol. 5, No. 1, 1987.
Journal of Cellular Biochemistry, UCLA Symposia on Molecular & Cellular Biology, Abstracts, 19thAnnual Meetings, Jan. 1990, Alan R. Liss, Inc.
Transcript of speech entitled “Particle Propulsion by electric Discharge at the AAAS Meeting on Plant Molecular Biology/Genetic Engineering for Agriculture (VI)”, Jan. 1989, by Winston Brill. Tape available from AAAS.
G. Acsadi et al., “Direct Gene Transfer and Expression into Rat Heart in Vivo”, The New Biologist, Jan. 1991, pp. 71-81, vol. 3, No. 1.
W.F. Anderson, “Gene Therapy—Several hundred patients have already received treatment. In the next century the procedure will be commonplace”, Scientific American, Sep. 1995, pp. 124-128, Scientific American Inc., New York, NY.
P. Anker et al., “The Role of Extracellular DNA in the Transfer of Information From T to B Human Lymphocytes in the Course of an Immune Response”, J. Immunogenet., 1980, pp. 475-481, vol. 7, Blackwell Scientific Publications.
P. Anker et al., “Nude Mice Injected with DNA Excreted by Antigen-Stimulated Human T Lymphocytes Synthesize Specific Human Antibodies”, Expl. Cell. Biol., 1984, pp. 133-136, vol. 52, Karger, Basel.
P. Anker et al., “Transfert d'information de lymphocytes T à B au cours d'une réponse immune: rôle de I'ADN extracellulaire”, Schweiz. Med. Wschr., 1980, pp. 1444-1446, vol. 110.
P. Anker et al., “Spontaneous Release of DNA by Human Blood Lymphocytes as Shown in an in Vitro System”, Cancer Res., Sep. 1975, pp. 2375-2382, vol. 35.
K. Anwer et al., “Synergistic Effect of Formulated Plasmid and Needle-Free Injection for Genetic Vaccines”, Pharm. Res., 1999, pp. 889-895, vol. 16, No. 6, Plenum Publishing Corporation.
J.D. Appel et al., “Asbestos fibers mediate transformation of monkey cells by exogenous plasmid DNA”, Proc. Natl. Acad. Sci USA, 1988, pp. 7670-7674, vol. 85, The National Academy of Sciences, Washington, DC.
R. Aubin et al., “Polybrene/DMSO-Assisted Gene Transfer”, Methods in Molecular Biology, 1991, pp. 35-43, vol. 7, Chapter 4, The Humana Press Inc., Clifton, NJ.
W. Bains, “Anti-idiotype Antibodies”, Biotechnology From A to Z (2d ed.), 1988, pp. 17-19, Oxford University Press.
Baker et al., “The Study of Biology: The Fourth Edition”, 1982, pp. 145-150, Addison-Wesley Publishing Company.
J.A. Bellanti, “Theories of Antibody Formation”, Immunology III, 1985, pp. 154-155, W.B. Saunders Company.
N. Benvenisty et al., “Direct introduction of genes into rats and expression of the genes”, Proc. Natl. Acad. Sci. USA, Dec. 1986, pp. 9551-9555, vol. 83, The National Academy of Sciences, Washington, DC.
H.M. Blau et al., “Molecular Medicine—Gene Therapy—A Novel Form of Drug Delivery”, The New England J. Med., Nov. 2, 1995, pp. 1204-1207, vol. 333, No. 18, Massachusetts Medical Society.
O.F. Borisova et al., “Secondary structure of nuclear precursors of the informational RNA (pre-mRNA)”, Mol. Biol. (Mosk), Sep.-Oct. 1976, pp. 1094-1102, vol. 10, No. 5.
L. Bouchard et al., “Tumorigenic Activity of Polyoma Virus and SV40 DNAs in Newborn Rodents”, Virology, 1984, pp. 53-64, vol. 135, Academic Press, Inc.
O. Boussif et al.,
Johnston Stephen A.
Sanford John C.
Bingham & McCutchen LLP
Cornell University
Crane Sharon E.
Crouch Deborah
Duke University
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