Radiant energy – Ionic separation or analysis – With sample supply means
Patent
1993-03-31
1994-07-19
Anderson, Bruce C.
Radiant energy
Ionic separation or analysis
With sample supply means
250282, B01D 5944, H01J 4900
Patent
active
053311604
ABSTRACT:
An LC/MS (liquid chromatography and mass spectrometry) system includes a particle-beam generator that handles aqueous inputs with enhanced efficiency. Helium from a helium source is passed through organic liquid in a bubbler. The organic liquid is maintained at about 4.degree. C. The resulting mixture of helium and organic vapor is used as a dispersant gas by the particle-beam generator. The dispersant gas contacts a predominantly aqueous liquid chromatography effluent before a nebulizer causes the effluent to break up into droplets. The solvent in the droplets is vaporized in a desolvation chamber. A momentum separator removes helium, organic vapor, and solvent vapor from an analyte particle beam. The analyte particle beam is directed to a mass spectrometer for identification and quantification. This LC/MS has demonstrated an improvement in signal strength of up to an order of magnitude relative to a similar LC/MS without the organic vapor in the dispersant gas.
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Anderson Bruce C.
Hewlett--Packard Company
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