Chemistry: analytical and immunological testing – Including sample preparation
Patent
1997-09-08
1999-06-15
Pyon, Harold Y.
Chemistry: analytical and immunological testing
Including sample preparation
436514, 436517, 436536, 436539, 4352872, 4352881, 422 73, G01N 33557, G01N 118
Patent
active
059121823
ABSTRACT:
A sample of liquid with suspended particles is contained in a tube and subjected to a standing wave ultrasound field transverse to the tube, the standing wave exhibiting a progressive change in pressure amplitude transverse to the tube, so that particles in suspension are displaced transversely of the tube to one or more predetermined regions; exposure of the sample to the standing wave is then terminated and the particles are allowed to settle, and inspected to determine whether they remain aggregated or whether they dissociate. The ultrasound field is produced by a transducer of tubular form encircling the tube. The invention may be used for agglutination of particles or cells via cross-bridging molecules in immuno-agglutination assays.
REFERENCES:
patent: 4615984 (1986-10-01), Stoker
patent: 4795698 (1989-01-01), Owen et al.
patent: 5164094 (1992-11-01), Stuckart
patent: 5227312 (1993-07-01), Grundy
patent: 5665605 (1997-09-01), Coakley et al.
Dyson, et al., "Segregation and Sedimentation of red Blood Cells in Ultrasonic Standing Waves", Nature,239, pp. 398-399, (1972).
Jepras, et al., "Agglutination of Legionella pneumophila by antiserum is accelerated in an ultrasonic standing wave", Journal of Immunological Methods, 120, pp. 201-205, (1989).
Whitworth, et al., "Transport and harvesting of suspended particles using modulated ultrasound", Ultrasonics, 29, pp. 439-444, (1991).
Bolek Werner
Coakley William Terence
Grundy Martin Alan
Pyon Harold Y.
University College Cardiff Consultants Limited
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