Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1996-12-05
1998-12-29
Chin, Christopher L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
73 6141, 73 6175, 73584, 73590, 73599, 73618, 73632, 73649, 422 20, 422 73, 422 8201, 4352871, 4352872, 436518, 436523, 436533, 436534, 436536, 436806, G01N 33546
Patent
active
058539948
ABSTRACT:
A system for assaying a fluid sample for one or more types of analytes, which employs at least one class of finely divided polystyrene spheroidal particles, each class being limited to a predetermined specific narrow range of particle diameters, the particles of each such class being coated with a specific reactant unique for that class. After the coated particles are mixed with the sample to specifically react to form conjugates of the particles and any of the analyte present, the mixture is irradiated with bursts of ultrasound swept over a range of frequencies resonant to the expected conjugate sizes. The presence of the conjugates and therefore the analyte is detected directly by measuring any selective absorption or scattering of waves of frequencies to which the conjugates are resonant.
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C.L. Cambiaso et al., "Particle Counting Immunoassay (PACIA). III. Automated Determination of Circulating Immune Complexes by Inhibition of an Agglutinating Factor of Mouse Serum", Journal of Immunological Methods, 28 (1979), pp. 13-23.
J.N. Limet et al., "Particle Counting Immunoassay. IV. The Use of F(ab').sub.2 Fragments and N.sup.68 -Chloroacetyl Lysine N-Carboxy-Anhydride for Their Coupling to Polystyrene Latex Particles", Journal of Immunological Methods, 28 (1979), pp. 25-32.
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Becker Edmund F.
Fallon John
Good, III Carl M.
Gopinathan Gopal
Li Xue-Song
Analogic Corporation
Chin Christopher L.
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