Partially retro-inverted decapeptide as a specific renin inhibit

Details Partially retro-inverted decapeptide as a specific renin inhibit Partially retro-inverted decapeptide as a specific renin inhibit

1984-05-22

1986-04-29

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

045855862

ABSTRACT:
Synthesis of an analogue of the (5-14) decapeptide of equine angiotensinogen partially retro-inverted at the Phe-Phe bond, of formula: ##STR1## The retro-inverso analogue inhibits renin with high resistance to enzymatic degradation, and can be used in the treatment of renin-dependent hypertension.

REFERENCES:
patent: 4439360 (1984-03-01), Verdini et al.
Szelke et al., Supp. II, Hypertension, vol. 4, No. 3, 59-69, (1982).

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