Partially purified bone-inducing factor

Details Partially purified bone-inducing factor Partially purified bone-inducing factor

1985-02-26

1986-12-09

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

260112R, 2601237, 435 68, 435 69, 435 70, 435268, 106122, 106161, 424 15, 514 21, 514801, 530416, 530417, A61K 3532

Patent

active

046279822

ABSTRACT:
A partially purified proteinaceous bone-inducing factor of 10,000 to 30,000 daltons is described. It is derived from demineralized bovine bone by extraction with a chaotropic agent, gel filtration, cation exchange chromatography using carboxymethyl cellulose at pH 4.8 and gradient elution with NaCl at 10 mM to about 150 mM.

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Urist et al. Proc. Natl. Acad. Sci. USA (1984), 81:371-375.
Journal of Biol. Chem., 256, 10403-10408, Termine et al.
Hanamura et al. Clin. Orthop. Rel. Res. 153, 232-240 (1980).

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