Partially protected human insulin-A-chain and process for its ma

Details Partially protected human insulin-A-chain and process for its ma Partially protected human insulin-A-chain and process for its ma

1978-09-06

1980-07-29

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601127, C07C10352

Patent

active

042150370

ABSTRACT:
Partially protected human insulin-A-chain suitable as intermediate for insulin synthesis and process for its manufacture by reacting the partially protected peptide fragment 6 to 26 of the insulin-A-chain with the peptide fragment 1 to 5 containing an N-terminal amino protective group capable of being split off by 5% strength trifluoroacetic acid in methylene chloride.

REFERENCES:
patent: 3883500 (1975-05-01), Geiger et al.
patent: 3994871 (1976-11-01), Kamber et al.
Cohen, Synthetic Studies on the A and B of Insulin, 9, (2), 1964, pp. 238-241.

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