Partially modified and retro-inverted tetrapeptides analogues of

Details Partially modified and retro-inverted tetrapeptides analogues of Partially modified and retro-inverted tetrapeptides analogues of

1996-02-28

1996-11-26

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530330, A61K 3807

Patent

active

055785751

ABSTRACT:
A method for treating septic shock by administering a retroinverted tetrapeptides of formula I ##STR1## wherein R is a hydrogen atom or the side-chain of threonine; R.sub.1 is the side-chain of arginine, leucine or glutamine; and R.sub.2 is a hydrogen atom or a metabolically perishable acyl group; with the proviso that when R.sub.1 is the side-chain of arginine, R cannot be the side-chain of threonine; diastereo-isomeric forms and pharmacologically acceptable salts, esters and amides thereof.

REFERENCES:
patent: 4816560 (1989-03-01), Verdini et al.
patent: 5521159 (1996-05-01), Verdini et al.
Biotechnology Newswatch, Aug. 1, 1994, pp. 1 and 4.
The Washington Post, Jan. 19, 1993, p. D3.
Cross, A et al (1993), Infection and Immunity 61, 2741-2747.

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