Partially lyophilized fructose-1,6-diphosphate (FDP) for injecti

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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A61K 3170

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057312915

ABSTRACT:
A method is disclosed for preparing a partially lyophilized (freeze-dried) powder or solidified cake containing fructose-1,6-diphosphate (FDP), a naturally-occurring intermediate in glycolysis. Preferably, about 10% to 25% residual water (by weight) is left in the powder or cake. This high moisture content does not degrade or limit FDP's stability or shelf life, and it provides for faster, less expensive processing. The methods disclosed herein also allow direct lyophilization inside a vial or other sealed container that will hold the lyophilized FDP, to avoid any need for milling, handling, or other treatment under conditions that might endanger its sterility. Lyophilized FDP can be used to create emergency injection kits which also contain aqueous solutions for mixing, and syringes and needles for injection. These kits can be carried in ambulances, police cars, firetrucks, etc., and can be stored at nursing homes, swimming pools, and in the homes of people suffering from various conditions such as heart disease or sicle cell anemia. These kits will allow rapid (even pre-diagnostic) injection of FDP into people suffering medical crises such as heart attacks, severe blood loss, suffocation, etc.

REFERENCES:
patent: 4530902 (1985-07-01), Perri et al.
patent: 4546095 (1985-10-01), Markov
patent: 4575549 (1986-03-01), Diana et al.
patent: 4703040 (1987-10-01), Markov
patent: 4870057 (1989-09-01), Chiapparelli et al.
patent: 5039665 (1991-08-01), Markov
patent: 5094947 (1992-03-01), Nakajima et al.
patent: 5434255 (1995-07-01), Katayama et al.
patent: 5506210 (1996-04-01), Parish et al.
patent: 5516526 (1996-05-01), da la Torre
patent: 5571906 (1996-11-01), Ceccarelli et al.
Chemical Abstracts 124: 56553 (1993). Ouyang et al.
WPIDS 133439 (1989). Cavicchia et al.
Angelos, M.G., et al, "Fructose-1, 6-diphosphate fails to limit early myocardial infarction size in a canine model," Ann. Emerg. Med. 22: 171-177 (1993).
Brunswick, R., et al, "Preservation of myocardium by infusion of fructose diphosphate following coronary occlusion," abstract, Am J Cardio 49: 1008 (1982).
Cargnoni, A., et al, "Role of timing of administration in the cardioprotective effect of fructose-1, 6-bisphosphate," Cardiovasc Drugs Ther 6: 209-217 (1992).
Conti, V.R., et al, "Metabolic and functional effects of carbohydrate substrate with single-dose and multipledose potassium cardioplegia," Ann. Thoracic Surg.36: 320-327 (1983).
de la Torre, J.C. "Treatment of head injury in mice, using a fructose 1,6-diphosphate and dimethyl sulfoxide combination," Nuerosurgery 37; 273-279 (1995).
Eddy, L.J., et al, "Lack of a direct metabolic effect of fructose, 1,6-disphosphate in ischemic myocardium," Am J Physiol 241: H576-583 (1995).
"Esafosfina" sales brochure (Biomedica Foscama: Ferentino, Italy.
Farias, L.A., et al, "Effects of fructose-1, 6-diphosphate, glucose and saline on cardiac resuscitation," Anesthesiology 65: 595-601 (1986).
Granot, H., et al, "Successful treatment of irreversible hemorrhagic shock in dogs with fructose-1,6 diphosphate and dichloroacetate," Circ Shock 163-173 (1985).
Haasinen, I.E., et al, "Mechanism of the effect of exogenous FDP on myocardial energy metabolism,"Circulation 83: 584-593 (1991).
Lazzarino G., et al, "Proctective effects of exogenously administered fructose-1,6-diphosphate from ischemia reperfusion damage induced on isolated rat heart,"Ital J Biochem 38: 251A-253A (1989).
Lazzarino, G., et al, "Ischemia and reperfusion: effect of fructose-1,6-bisphosphate,"Free Radic Res Commun 16; 325-339 (1992).
Marchionni, N., et al, "Hemodynamic and electrocardiographic effects of fructose-1,6-diphosphate in acute myocardial infarction," Am J Cardiol 56: 266-269 (1985).
Markov, A.K., et al, "Prevention of arrhythmias with fructose disphosphate in acute myocardial ischemia," abstract, Circulation 62: III-143 (1980).
Markov, A.K., et al, "Hemodynamic, electrocardiographic, and metabolic effects of fructose diphosphate on acute myocardial ischemia," Am Heart J 100: 639-646 (1980).
Markov, A.K., "Hemodynamic, and metabolic effects of fructose 1-6 diphosphate in inschemia and shock--experimental and clinical observations," Ann Emerg Med 15: 1470-7 (1986).
Markov, A.K., et al, "Increasing survival of dogs subjected to hemorrhagic shock by administration of fructose 1-6 diphosphate," Surgery 102: 515-527 (1987).
Mouchawar, A., et al, "A pathophysiological approach to the patient in shock, " Int Anesthesiol. Clin. 31: 1-20 (1993).
Pasque, M.K., et a, "Metabolic intervention to affect myocardial recovery following ischemia,"Annal of Surgery 200: 1-12 (1984).
Sernov, L.N., et al, "The characteristics of the cardioproctective action of fructose-1,6-diphosphate," Biull Eksp Biol Med 111: 172-173 (1991) (abstract).
Sernov, L.N., et al, "The antiacidotic and cardioprotective effects of fructose-1,6-diphosphate and dehydroascorbic acid," Farmakol Toksikol 54: 24-26 (1991) (abstract).
Sernov, L.N., et al, "A comparative evaluation of the cardioprotective and antianginal actions of energy-providing agents," Eksp Klin Farmakol 55:13-15 (1992) (abstract).
Stryer, L., Biochemistry, 2nd ed., pp. 266-267 (Freeman & Co., San Francisco, 1981).
Tortosa, A., et al, "Fructose-1,6-bisphosphate fails to ameliorate delayed neuronal death in the CA1 area after transient forebrain ischaemia in gerbils," Neuropharmacology 32: 1367-1371 (1992).
Zhang, J.N., et al, "Protective effect of exogenous fructose-1,6-disphosphate in cardiogenic shock," Cardiovasc Res 22: 927-932 (1988).

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