Partially fused peptide pellet

Details Partially fused peptide pellet Partially fused peptide pellet

1988-03-02

1991-08-13

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 14, 514 15, 514 16, 514 17, 514 18, 514 19, 514800, C07K 1708

Patent

active

050396609

ABSTRACT:
A bioerodible pellet capable of administering an even and continuous dose of a peptide over a period of up to a year, when subcutaneously implanted, is provided. The bioerodible implant is a partially-fused pellet, which pellet has a peptide drug homogeneously-bound in a matrix of a melted and recrystallized, nonpolymer carrier. Preferably, the nonpolymer carrier is a steroid and in particular is cholesterol or a cholesterol derivative. In one embodiment, the peptide drug is growth hormone-releasing hormone. A method for making the bioerodible pellet also is provided.

REFERENCES:
patent: 4164560 (1979-08-01), Folkman et al.
patent: 4591496 (1986-05-01), Cohen et al.
patent: 4667014 (1987-05-01), Nestor, Jr. et al.
patent: 4801577 (1989-01-01), Nestor, Jr. et al.

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