Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1995-01-06
1997-02-11
Kunz, Gary L.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 935, 424 96, 435101, 530322, 536 111, 536 41, 536 185, 536119, 536123, 536 187, 514 8, 514 54, A61M 3600, A61K 31715, A61K 5106
Patent
active
056017995
ABSTRACT:
The present invention relates to a D 25 polysaccharide compound whose lipid has been partially removed and to its derivatives, wherein at least 85% by weight, preferably 90% of the compound, exists in aqueous solution in monomeric form. The 30 kD molecular weight polysaccharide compound extracted from the membrane proteoglycan of the bacterium Klebsiella pneumoniae is mentioned in particular. The amount of palmitic fatty acids which is bound to it in esterified form does not exceed 0.01% by weight of the compound and the amount of palmitic fatty acids which is associated with it in the free form does not exceed 0.1% by weight of the compound.
REFERENCES:
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patent: 4937327 (1990-06-01), D'Hinterland et al.
Acta Path, Microbiol. Scand, Section C, vol. 93, 1985, pp. 233-243, G. Normier et al., "NK-Cell Stimulating Properties of a Membrane Proteoglycane from Non-Capsulated Klebsiella Pneumoniae Biotype a".
Chemical Abstracts, vol. 108, No. 7, Feb. 15, 1988, Columbus, Ohio, Abstract 487265, Sinilova N. G. et al., "Chemical Structure and the Immunostimulating Activity of High-Molecular-Weight Polysaccharides", p. 17.
Binz Hans
Delassan Souhail
Dussourd d'Hinterland Lucien
Favaron Michel
Le Pape Alain
Fonda Kathleen Kahler
Kunz Gary L.
Pierre Fabre Medicament
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