Partial modulation via pulsed flow modulator for...

Chemistry: analytical and immunological testing – Including chromatography

Reexamination Certificate

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C436S053000, C422S070000, C422S089000, C422S082000, C073S023410, C073S023420, C073S061550, C073S061560, C095S086000, C096S103000, C096S104000, C210S198200, C210S656000

Reexamination Certificate

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07091044

ABSTRACT:
This invention is a method and device for use with multi-dimensional chromatography that utilizes partial modulation. An analyte-bearing sample is subjected to a first dimension of chromatography. Thereafter the separated analyte-bearing sample is diluted with a modulated second carrier such at the analyte-bearing sample is not stopped or its temperature altered. The partially modulated analyte-bearing sample then feeds into a secondary column where the analyte-bearing sample is further separated.

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Philip J. Marriott, “Time-Resolved Cryogenic Modulation for Targeted Multidimensional Capillary Gas Chromatography Analysis”, The Journal of Chromatography, 2000, 15-28, 892.
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Matthias Pursch et al., “Modulation Techniques and Applications in Comprehensive Two-Dimensional Gas Chromatograpy (GCXGC),” Analytical Bioanalytical Chemistry, Jan. 9, 2002.

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