Partial and full agonists of A 1 adenosine receptors

Details Partial and full agonists of A 1 adenosine receptors Partial and full agonists of A 1 adenosine receptors

2006-12-05

2006-12-05

Jiang, S. Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S027230

Reexamination Certificate

active

07144871

ABSTRACT:
Disclosed are novel compounds that are partial and full A1adenosine receptor agonists, useful for treating various disease states, in particular tachycardia and atrial flutter, angina, myocardial infarction and hyperlipidemia.

REFERENCES:
patent: 6258793 (2001-07-01), Palle et al.
patent: 6294522 (2001-09-01), Zablocki et al.
patent: 6576619 (2003-06-01), Blackburn et al.
patent: 6576620 (2003-06-01), Belardinelli et al.
patent: 6605597 (2003-08-01), Zablocki et al.
patent: WO 99/67262 (1999-12-01), None
patent: WO 01/40799 (2002-07-01), None
patent: WO 02/70532 (2002-09-01), None
patent: WO03/070739 (2003-08-01), None
Dalpaiz et al. (I), “Characterization of Potential Adenosine A1Receptor Prodrugs of Adenosine Derivatives with Antiischemic Properties,”Acta Technologiae et Legis Medicamenti, 13(1), 49-57 (2002);Chemical Abstracts, 138, Abstr. No. 215195, HCAPlus No. 660483 (2002); only HCAPlus Abstract supplied.
Van Tilberg et al. (II), “5′ -O-Alkyl Ethers of N,2-Substituted Adenosine Derivatives: Partial Agonists for the Adenosine A1and A3Receptors,”Journal of Medicinal Chemistry, 44(18), 2966-2975 (Aug. 30, 2001).
Dalpaiz et al. (II), “Synthesis and Study of 5′-Ester Prodrugs of N6-Cyclopentyladenosine, a Selective A1Receptor Agonist,”Pharmaceutical Research, 18(4), 531-536 (2001).
Prashad et al., “Steric Effect of a Bulky Substituent at 5′-Position on the Regiospecificity of 2′- vs. 3′-O-Methylation of N6-Cyclohexyladenosine,”Nucleosides&Nucleotides, 13(4), 945-952 (1994);Chemical Abstracts, 122, Abstr. No. 81841, HCAPlus No. 14215 (1995); only HCAPlus Abstract supplied.
Maillard et al., “Adenosine Receptor Prodrugs: Synthesis and Biological Activity of Derivatives of Potent, A1-Selective Agonists,”Journal of Pharmaceutical Sciences, 83(1), 46-53 (Jan., 1994).
(W) Dhalla et al., “Pharmacology and Therapeutic Applications of A1 Adenosine Receptor Ligands,” Current Topics in Medicinal Chemistry, 3(4), 369-385 (2003).
Dhalla et al., “Pharmacology and Therapeutic Applications of A1Adenosine Receptor Ligands,”Current Topics in Medicinal Chemistry, 3(4), 369-385 (2003).

Affiliated with

Also associated with

Rating

Partial and full agonists of A 1 adenosine receptors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Partial and full agonists of A 1 adenosine receptors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Partial and full agonists of A 1 adenosine receptors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3695596