Partial agonists of the strychnine insensitive glycine modulator

Details Partial agonists of the strychnine insensitive glycine modulator Partial agonists of the strychnine insensitive glycine modulator

1989-08-08

2000-01-25

Geist, Gary

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514561, 560124, A61K 31215

Patent

active

060179570

ABSTRACT:
A method is disclosed for the treatment of neuropsychopharmacological disorders which are associated with or result from excessive activation of the N-methyl-D-aspartate receptor complex, which method comprises administering an effective neuropsychopharmacological disorder-treating amount of a compound possessing partial agonist properties for the strychnine insensitive glycine modulatory sites of N-methyl-D-aspartate receptors. Exemplary of partial agonists which are useful in the method of the invention are 1-aminocyclopropanecarboxylic acid, and associated derivates thereof. Novel injectable pharmaceutical compositions are also disclosed.

REFERENCES:
patent: 4491589 (1985-01-01), Dell et al.
patent: 4554017 (1985-11-01), Schroder et al.
patent: 4746653 (1988-05-01), Hutchison et al.
patent: 5086072 (1992-02-01), Trullus et al.
Bonta et al, Brit. J. Pharmacol. 43(3) 514-35, 1971.
Singh et al Proc. Natl. Acad. Sci. USA 87, 347-351, 1990.
Nadler et al, European Journal of Pharmacology, vol. 157, pp. 115-116, 1988.
Marvizon et al, J Neurochem, vol. 52, p. 992-994, 1989.
Robinson et al, FASEB J, vol. 1, pp. 446-455, 1987.
Faster et al, Nature, vol. 392, pp. 395-396, 1987.
P. Skolnick et al, Life Sciences, vol. 45, No. 18 (1989), pp. 1647-1655.
R. Trullas et al, Pharm.Bioch. & Beh., vol. 34, (1989), pp. 313-316.
D. W. Choi, Neuron, vol. 1, Oct. 1988, pp. 623-934.
J. T. Winslow et al, Europ. J. of Pharm., vol. 190 (1990), pp. 11-21.
J. D. Leander et al, Brain Research, vol. 448 (1988), pp. 115-120.
J. Lehman et al, Drug Discov. Div., Ciba-Geigy Corp., pp. 31-40.
C. Cotman et al, J. of NIH Res., vol. 1, pp. 65-74 (1989).
J. W. Olney, Biol. Psychiatry, vol. 26, (1989), pp. 505-525.

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