Paromomycin or its derivatives or salts thereof in combination w

Details Paromomycin or its derivatives or salts thereof in combination w Paromomycin or its derivatives or salts thereof in combination w

1994-12-05

1995-11-28

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 23, 514503, 536 133, A61K 3170

Patent

active

054708362

ABSTRACT:
A compound of formula (I): ##STR1## wherein: R.sub.1 is a hydroxy group or an amino group optionally substituted with a C.sub.1 -C.sub.4 alkyl or phenyl-(C.sub.1 -C.sub.4) alkyl group,
R.sub.2 is hydrogen or a hydroxy group,
R.sub.3 is hydrogen or chlorine,
R.sub.4 is hydrogen or a hydroxy or amino group,
R.sub.5 is hydrogen or a hydroxy group, and
R.sub.6 is hydrogen or a hydroxy group,
or a non-toxic acid addition salt thereof, is useful in the parenteral treatment of visceral leishmaniasis or malaria, and a synergistic composition comprising a compound of formula (I) or a non-toxic acid addition salt thereof and sodium stibogluconate is useful in the treatment of visceral leishmaniasis.

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Annals of Tropical Medicine and Parasitology, vol. 69, No. 3, 1975, N. M. Mattock et al.: "The experimental chemotherapy of leishmaniasis, II: The activity in tissue culture of some antiparasitic and antimicrobial compounds in clinical use", pp. 359-371.
Antimicrobial Agents and Chemotherapy, vol. 26, No. 5, Nov. 1984, American Society for Microbiology, J. El-On et al.: "Development of topical treatment for cutaneous Leishmaniasis caused by Leishmania major in experimental animals", pp. 745-751.
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Dermatologia Venezolana 24, 1986, pp. 82-84, Nuevo Tratamiento Para La Leishmaniasis Tegumentaria, Scorza, J. V. et al.
Ann. Trop. ed. Parasit., 1968, vol. 62, pp. 54-62, The effects of antibiotics of the neomycin group on experimental cutaneous leishmaniasis, R. A. Neal.
Rev. Cub. Med. Trop., 34, Jan.-Apr. 1982, pp. 34-45, Quimioterapia experimental en hamsteres, por paramomicina, contra dos aislados de Leishmania mexicana y Leishmania braziliensis, S. Rezzano et al.
Report on XIIth International Congress for Tropical Medicine and Malaria, Sep. 18-23, 1988, Amsterdam, Wes-4-4, Improved treatment of visceral leishmaniasis using a combination of aminosidine plus sodium stibogluconate, C. N. Chunge.

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