Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase
Patent
1997-07-03
1999-07-13
Leary, Louise N.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving hydrolase
435 71, 435 4, 436 63, C12Q 134, C12Q 100, G01N 3348
Patent
active
059225564
ABSTRACT:
This invention provides methods of determining the susceptibility to Parkinson's disease of a subject and of diagnosing Parkinson's disease in a subject which comprises detecting in a sample from the subject the presence of a composition of matter, which composition comprises a band having an apparent molecular weight of about 83 kilodaltons as determined by denaturing polyacrylamide gel electrophoresis, is capable of being specifically detected by an antibody directed to mitochondrial aconitase hydroxylase, and has greater electrophoretic mobility than the corresponding unaltered composition as determined by non-denaturing polyacrylamide gel electrophoresis.
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Freyer Greg
Graziano Joseph
Mayeux Richard
Leary Louise N.
The Trustees of Columbia University in the City of New York
White John P.
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