Parital primary amino acid sequence of the antineoplastic protei

Details Parital primary amino acid sequence of the antineoplastic protei Parital primary amino acid sequence of the antineoplastic protei

1993-09-02

1994-03-29

Schain, Howard E.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

530350, 530380, C07K 1512

Patent

active

052986047

ABSTRACT:
Electrophoretically homogeneous human Antineoplastic Urinary Protein (ANUP) contains a blocked N-terminal amino acid that has been identified as pyroglutamic acid. Removal of the pyroglutamy residue by the use of pyroglutamyl aminopeptidose results in the formation of the deblocked protein which is also an antineoplastic molecule. The amino acid sequence of the deblocked ANUP 16 KD monomer showed the following sequence:
Cycle No.

REFERENCES:
patent: 4359415 (1982-11-01), Sloane
patent: 4559325 (1985-12-01), Burzynski
patent: 5008372 (1991-04-01), Wellner
Sloane et al. Biochemical Journal (1986), 234, pp. 355-362.
Pottahil et al, Cancer Therapy and Control (1990), 1, pp. 193-198.
Sloane et al, FASEB Journal (1991), 5 A546, Abstract #1019.

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