Parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl

Details Parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl Parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl

1997-05-27

1998-09-29

Weddington, Kevin E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Para-n-benzene - sulfoxy-n containing doai, and said benzene...

514258, 514259, A61K 3163, A61K 31505

Patent

active

058146237

ABSTRACT:
Disclosed herein are parenteral solutions containing 7-halo-1,2,3, 4-tetrahydro-3-aryl-6-quinazoline sulfonamide in Tris or Bis-Tris or Tris buffer useful in the treatment of hypertension, heart disease and heart failure and renal disease. Also disclosed are methods for preparing such solutions.

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patent: 5633240 (1997-05-01), Ranade
patent: 5684009 (1997-11-01), Ravade
Windholz et al., The Merck Index, 10th Ed. (Merck & Co) 1983, p. 615 ab No. 418b ad p. 1395, ab No 9575, 1983.
Bennett, William et al., "Comparison of Intravenous Chlorothiazide and Metolazone in Normal Man", Current Therapeutic Research, (1977), 22: 326-334.
Grosskopf, I. et al., "Combination of Furosemide and Metolazone in the Treatment of Severe Congestive Heart Failure", Israel Journal of Medical Sciences, (1986), 22: 787-790.

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