Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-01-26
2000-04-11
Reamer, James H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3147
Patent
active
060488743
ABSTRACT:
The invention provides a method of making a pharmaceutical composition comprising a solution, which method comprises: (a) providing a solvent comprising propylene glycol, polyethylene glycol, polypropylene glycol, or glycerin; and (b) adding metolazone. The final concentration of metolazone in the solution is 9 mg/ml or more, the metolazone is not precipitated, and the concentration of metolazone is above its apparent equilibrium solubility. The invention also provides a pharmaceutical composition comprising a solution comprising: (a) a solvent other than water; and (b) 9 mg/ml or more of metolazone. The metolazone is not precipitated in this solution and the concentration of metolazone is above its apparent equilibrium solubility.
REFERENCES:
patent: 4472380 (1984-09-01), Harris et al.
patent: 4517179 (1985-05-01), Raghunathan
patent: 4522818 (1985-06-01), Raghunathan
patent: 5124152 (1992-06-01), Biringer et al.
patent: 5246944 (1993-09-01), Greenlee et al.
patent: 5633240 (1997-05-01), Ranade
patent: 5684009 (1997-11-01), Ranade
patent: 5814623 (1998-09-01), Ranade
Belair, "the Renal Pharmacology of Metolazone, 2-Methyl-3-0-Tolyl-6-Sulfamyl-7-Chloro-1,2,3, 4-Tetrahydro-4-Quinazolinone," Research Communications in Chemical Pathology and Pharmacology, vol. 2, No. 1, pp. 98-117 (1971).
Bennett et al., "Comparison of Intravenous Chlorothiazide and Metolazone in Normal Man," Current Therapeutic Research, vol. 22, No. 2, pp. 326-334 (1977).
Cohen et al., "Physiological Disposition of a New Diuretic, .sup.14 C-Metolazone, in Dogs," J. Pharmaceutical Sciences, vol. 62, No. 6, pp. 931-936 (1973).
Grosskopf et al., "Combination of Furosemide and Metolazone in the Treatment of Severe Congestive Heart Failure," Israel Journal of Medical Sciences, vol. 22, No. 11 pp. 787-790 (1986).
Santelli Ronald J.
Tu Yu-Hsing
Medeva Pharmaceuticals Manufacturing, Inc.
Reamer James H.
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