Parenteral dosage form

Details Parenteral dosage form Parenteral dosage form

1993-07-14

1997-07-01

Marquis, Melvyn I.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

264 13, 264 5, 514177, 514178, 514182, A61K 910, A61K 916, A61K 31565

Patent

active

056436041

ABSTRACT:
Delayed-release formulation intended for administration by parenteral injection, consisting of solid calibrated microspheres (5-300 .mu.m) comprising a pharmaceutically active substance (for example: morphine) contained in spherical structures determined by one or more which are pharmacologically inactive carrier substances (for example: cholesterol), naturally present in the receiving organism, which are pharmacodynamically inactive at the administered doses of said dosage form, having a melting point greater than 60.degree. C. and stable in the solid state in the receiving physiological medium. The dosage form makes it possible to slow and prolong the effect of active substances which are too rapidly soluble in physiological medium (which act on the central nervous or neurovegetative system, such as vasedilators, anti-histaminics, hormones, contraceptives and the like).

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