Parenteral delivery of MAO A inhibitors

Details Parenteral delivery of MAO A inhibitors Parenteral delivery of MAO A inhibitors

1996-10-10

1998-08-11

Spivak, Phyllis G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514647, 514654, 514655, A61K 31135

Patent

active

057927995

ABSTRACT:
Methods of treating Parkinson's disease in a human by administering an effective amount of at least one monoamine oxidase (MAO) A inhibitor by a nasal, intrapulmonary or parenteral routes are disclosed. Reversible or irreversible MAO A inhibitors, or non-selective MAO inhibitors, can be used, and more than one MAO A inhibitor can be administered concurrently. The MAO A inhibitor can be administered in conjunction with other drugs, such as MAO B inhibitors.

REFERENCES:
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Riederer, P., et al., "Monoamine Oxidase Activity and Monoamine metabolism in Brains of Parkinsonian Patients Treated with 1-Deprenyl" J. of Neurochemistry, 46:1359-1365 (1986).
Butcher, S.P., et al., "Effects of Selective Monoamine Oxidase Inhibitors on the In Vivo Release and Metabolism of Dopamine in the Rat Striatum", J. of Neurochemistry, 55:981-988 (1990).
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Yu, P.H., et al., "Differential Expression of Type A and Type B Monoamine Oxidase of Mouse Astrocytes in primary Cultures", J. of Neurochemistry, 39:1492-1495 (1982).
Aulakh et al., Pharmacol., Biochem. Behav., 55(2), 265-8 (1996).
Brannan et al., J. Neural Trausm.: Parkinson's Dis. Dementia Sect., 10(2-3), 79-89 (1995).

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