Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1980-07-15
1982-07-27
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
23230B, 424, G01N 3356
Patent
active
043417558
ABSTRACT:
A method for the radioimmunoassay of parathyroid hormone in mammalian serum. The method is an improvement on previous double antibody radioimmunoassays in that spurious assay results caused by the nonspecific interaction of serum proteins with the labeled peptide is eliminated by the labeling of a specific portion of either human or bovine parathyroid molecule. The 65-84 portion of human or bovine parathyroid hormone, as radioactively labeled, is incorporated in the assay as the labeled peptide. A chicken antibody with a high affinity for the 65-84 portion of human parathyroid hormone is incorporated in the assay as the first antibody. The invention further pertains to compounds useful in practicing the method, namely X.sup.64 -hPTH.sup.65-84 and Y-X.sup.64 -hPTH.sup.65-84 wherein X is either histidyl, tyramyl, histamyl, or tyrosyl, and wherein Y is either .sup.125 I or .sup.131 I.
REFERENCES:
patent: 4146602 (1979-03-01), Gutcho et al.
Stewart et al., Solid Phase Peptide Synthesis, 2nd ed., Freeman & Co., 1968, pp. 1-26.
Lindall, Presentation Congesso Sanitario Delgi Ospedali Galliera, Oct. 1978.
Jaffe et al., Methods of Hormone Radioimmunoassay, 2nd ed., Academic Press, 1979, chapter 19.
Parthemore et al., J. Clin. Endo. Met., 47:248-289, (1978).
Di Bella et al., Clin. Chem., 24:451.varies.454, (1978).
Evr. J. Clin. Invest., 8:149-154, (1978).
Health, III et al., Clin. Chem., 24:1833-1835, (1978).
Di Bella et al., J. Clin. Endocrin. Met., 46:604-612.
Arnauld et al., J. Clin. Inves., 50:21-34, (1971).
Immuno Nuclear Corporation
Nucker Christine M.
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