Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1997-07-30
2000-11-14
Moezie, F. T.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530300, 514 12, C07K 14635
Patent
active
061471860
ABSTRACT:
The present invention relates to novel PTHrP analogs that have been converted into potent PTH-2 receptor agonists or antagonists by the substitution of one or more amino acid residues of PTHrP to the corresponding residue(s) of PTH. A method of treating various disease states associated with altered function of the PTH-2 receptor, using these PTHrP analogs, is also described.
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International Search Report for International Application No. PCT/US97/13360.
Gardella Thomas J.
Juppner Harald
Moezie F. T.
The General Hospital Corporation
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