Parathyroid hormone receptor ligands

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence

Reexamination Certificate

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Reexamination Certificate

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07122624

ABSTRACT:
An isolated or purified PTH2 receptor ligand or PTH1 receptor ligand is disclosed.

REFERENCES:
patent: 3886132 (1975-05-01), Brewer et al.
patent: 5194375 (1993-03-01), Park et al.
patent: WO 98/04591 (1998-02-01), None
patent: WO 02/33049 (2002-04-01), None
Angal et al. “Purification by exploitation of activity” Chapter 5, In, Protein Purification Methods: A Practical Approach, Harris et al. (Eds.), Sep. 1989, IRL Press, Oxford, UK, pp. 245.
Guo et al. Protein tolerance to random amino acid change. Proc Natl Acad Sci U S A. Jun. 22, 2004;101(25):9205-10.
Gardella, T. J., et al. (1996) Converting Parathyroid Hormone-related Peptide (PTHrP) into a Potent PTH-2 Receptor Agonist. J. Biol. Chem. 271(33):19888-19893.
Hoare, S. R. J., et al. (1999) Comparison of Rat and Human Parathyroid Hormone 2 (PTH2) Receptor Activation: PTH Is a Low Potency Partial Agonist at the Rat PTH2 Receptor. Endocrinology 140(10):4419-4425.
Hoare, S. R. J., et al. (2000) Tuberoinfudibular Peptide (7-39) [TIP(7-39)], a Novel, Selective, High-Affinity Antagonist for the Parathyroid Hormone-1 Receptor with No Detectable Agonist Activity, JPET 295(2):761-770.
Hoare, S. R. J., et al. (2000) Molecular Determinants of Tuberoinfundibular Peptide of 39 Residues (TIP39) Selectively for the Parathyroid Hormone-2 (PTH2) Receptor. J. Biol. Chem. 275(35):27274-27283.
Mezey, E., et al. (1998) Anatomical Studies of the Rat PTH2 Receptor. Society for Neuroscience 24:244 (Abstract).
Nakata, T., et al. (1995) Role of Basic and Acidic Fragments in Delicious Peptides (Lys-Gly-Asp-Glu-Glu-Ser-Leu-Ala) and the Taste Behavior of Sodium and Potassium Salts in Acidic Oligopeptides. Biosci. Biotech. Biochem. 59(4):698-693.
Usdin, T. B., et al. (1995) Identification and Function Expression of a Receptor Selectively Recognizing Parathyroid Hormone, the PTH2 Receptor. J. Biol. Chem. 270(26):15455-15458.
Usdin, T. B., et al. (1996) Distribution of Parathyroid Hormone-2 Receptor Messenger Ribonucleic Acid in Rat. Endocrinology 137(10):4285-4297.
Usdin, T. B. (1997) The parathyroid hormone-2 receptor: current status. Exp. Mol. Med. 29(1):13-17.
Usdin, T. B. (1997) Evidence for a Parathyroid Hormone-2 receptor selective ligand in the hypothalamus. Endocrinology 138(2):831-834.
Usdin, T. B., et al. (1998) Progress on the Identification of a Novel PTH2 Receptor-Selective Peptide From the Hypothalamus. Society for Neuroscience 24:2044 (Abstract).
Usdin, T. B., et al. (1999) Distribution of the Parathyroid Hormone 2 Receptor in Rat: Immunolocalization Reveals Expression by Several Endocrine Cells. Endocrinology 140(7):3363-3371.
Usdin, T. B., et al. (1999) TIP39: a new neuropeptide and PTH2-receptor agonist from hypothalamus. Nature Neuroscience 2(11):941-943.
Usdin, T. B. (2000) The PTH2receptor and TIP39: a new peptide-receptor systemm. TIPS 21:128-130.

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