Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1998-03-19
2000-02-15
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
514 12, C07K 706, A61K 3816
Patent
active
06025467&
ABSTRACT:
Disclosed is a parathyroid hormone (PTH) (1-34) derivative in which at least the amino acid residue at the 10-position is substituted by an acidic amino acid residue. The derivatives of the present invention showing potent cAMP-producing activity and bone formation activity, and thus are useful as therapeutic agents for bone diseases, etc.
Fukuda Tsunehiko
Habashita Junko
Nakagawa Shizue
Taketomi Shigehisa
Borin Michael
Conlin David G.
O'Day Christine C.
Takeda Chemical Industries Ltd.
Tsang Cecilia J.
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