Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1987-05-26
1988-09-13
Phillips, Delbert R.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
C07K 710
Patent
active
047711248
ABSTRACT:
The present invention relates to the use of peptide hormone analogues as inhibitors of their respective naturally occurring peptide hormone and methods of synthesis of such analogues. The structure of the peptide hormone analogues is exemplified by parathyroid hormone wherein Trp.sup.23 is substituted by L-Phe or other hydrophobic amino acids such as Leu, Nle, Val, Tyr, beta-napthylalanine and alpha-napthylalanine.
REFERENCES:
patent: 3886132 (1975-05-01), Brewer et al.
Caporale Lynn H.
Chorev Michael
Levy Jay J.
Nutt Ruth F.
Rosenblatt Michael
Caruso Charles M.
Merck & Co. , Inc.
Pfeiffer Hesna J.
Phillips Delbert R.
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